[Pharmwaste] Does 'the dose make the poison?' Extensive results challenge a core assumption in toxicology

[DeBiasi,Deborah]

This article has some great graphs and pictures that won't show up on
the list serve:

http://www.environmentalhealthnews.org/sciencebackground/2007/2007-0415n
mdrc.html
  
The "dose makes the poison" is a common adage in toxicology. It implies
that larger doses have greater effects than smaller doses. That makes
common sense and it is the core assumption underpinning all regulatory
testing. When "the dose makes the poison," toxicologists can safely
assume that high dose tests will reveal health problems that low dose
exposures might cause. High dose tests are desirable because, the logic
goes, they not only will reveal low dose effects, they will do so faster
and with greater reliability. Greater reliability and speed also mean
less cost. 



Deborah L. DeBiasi
Email:   dldebiasi at deq.virginia.gov
WEB site address:  www.deq.virginia.gov
Virginia Department of Environmental Quality
Office of Water Permit Programs
Industrial Pretreatment/Toxics Management Program
Mail:          P.O. Box 1105, Richmond, VA  23218 (NEW!)
Location:  629 E. Main Street, Richmond, VA  23219
PH:         804-698-4028
FAX:      804-698-4032