[Pharmwaste]Measuring the amount - French hospital modeling exercise

[Price, John L.]

J. U. Mullot: Thank you for this very interesting and detailed post on the
variables involved in correlating sales, pharmacokinetics and environmental
concentrations and, especially, how your hospital modeling exercise proposes
to account for them.  Please keep the Listserve posted on results on your
important work. 

 

Jack

 

John L. (Jack) Price

Environmental Manager

Hazardous Waste Management MS 4555

Florida Department of Environmental Protection

2600 Blair Stone Road

Tallahassee, FL  32399-2400

Phone:850.245.8751

Fax: 850.245.8811

john.l.price at dep.state.fl.us

www.dep.state.fl.us/waste

Please Note:  Florida has a very broad public records law.  Most written
communications to or from state officials regarding state business are public
records available to the public and media upon request.  Your e-mail is
communications and may therefore be subject to public disclosure.

  _____  

From: pharmwaste-bounces at lists.dep.state.fl.us
[mailto:pharmwaste-bounces at lists.dep.state.fl.us] On Behalf Of
JuMullot at aol.com
Sent: Friday, February 23, 2007 8:36 AM
To: pharmwaste at lists.dep.state.fl.us
Subject: [Pharmwaste] Re: Pharmwaste Digest, Vol 16, Issue 24

 

Dans un e-mail daté du 22/02/2007 07:24:56 Paris, Madrid,
pharmwaste-request at lists.dep.state.fl.us a écrit :

	Responding to "Measuring the amount...."

Dear Collegues,

 

I'm a european (French) doctorant, following your discussions in this forum
since several month and I would like to share my opinion about the
measurment/modelling of pharmaceutical amounts in aquatic ressources.

 

In europe also, it is quite easy to find consumption data in financial units
($ or euros) but it is something very very difficult to find a robust
correlation between financial units and amounts (in mass of active ingredient
for example) for the following reasons :

 

- public prices are controlled (in france) but not for hospitals, clinics and
health centers (in this case, prices are free of regulatory control). For
example, you can pay a lot for a molecule in the pharmacy store just located
in your street but the same molecule can be provided for no charge at the
hospital pharmacy where you can be hospitalized ... but an other hospital
pharmacy can pay a different price because they do not negociate,

 

- for a same active ingredient you can have different presentations and/or
routes of administration and the prices can be very different between these
presentations,

 

- between the sales and the environment you have humans that can metabolize
the active ingredient and pharmacokinetic data are not always avalaible
and/or of good quality for modelling purposes (and there are interindividual
variations of pharmacokinetic data)

 

In my opinion, this is a reason why mesured environmental concentrations and
predicted environmental concentrations do not often correlate, especially
when calculated with amounts derived from financial informations.

 

For these reasons I'm actually trying to build a model at the hospital scale
with daily amounts delivered in patients (in g of active ingredient), daily
water consumptions and PBPK data as main variables and we compare measured
concentrations in hospital wastewater (proportional sample) with calculated
concentrations for several API of each major therapeutic class (about 15
target molecules) and for different hospitals. First data will be avalaible
in few months ... for integration in other models from urban wastewater to
other environmental compartments.

 

To my knowledge a firm, called "IMS Health" can provide data of API
consumption in mass amounts but you should pay for that. The website adress
is http://www.imshealth.com/

 

Ready to answer you questions and discuss again about this subject,

 

Best regards,

 

Jean Ulrich MULLOT

Pharmacist, Doctorant in Human and Environmental Risk Assessment (mainly
exposure assessment)

 

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