[Pharmwaste] Re: Pharmwaste Digest, Vol 46, Issue 22

[randsney at comcast.net]

August 17, 2009

Pharmwaste



In many cases the degradation products are unknown in the environment and 
there may be no analytes available to track the residues (parent and 
degradation products). The residues may be small but may be bio-accumulate 
in the human or other animal bodies.



Do the methods extract residues that have a high Koc (organic carbon 
partition coefficient) value in soil or a high Kow (octanol water partition 
coefficient) value in fat tissue? If you want to know these values read my 
book, Fate and Transport of Organic Chemicals in the Environment (third 
edition). Bottom line answer is almost all the methods have not been 
validated for total residues that are extracted and those that are not 
extracted but available for uptake by plants and animals. In other words 
there is no material balance for parent chemical and its degradation 
products. Fortifying a matrix and extracting does not prove that an 
extraction procedure will work for chemicals aged in the matrix over time 
(i.e. 30, 60 & 120 days). If you want additional info on extraction methods 
I will provide.



Many may say exposure to chemicals and their degradation products, and/or 
biologicals in consumer products, in the environment, etc. is so small there 
is little chance of risk.  While this may be true in many cases, safety 
cannot be judged on one chemical or one biological alone.  Humans and other 
animals are a mixture of chemicals and their degradation products, and 
biologicals, and we take in hundreds of different chemicals and biologicals 
a year. How safe are these chemicals and their degradation products, 
(pesticides, hormones, metals, etc.) and biologicals when the aggregate, 
synergistic, antagonistic, co-metabolism and co-biometabolism effects are 
never mentioned or studied to any extent, if at all and, they are not used 
in risk assessments?  In other words, the total picture is never known or 
considered for hazards to adults, child endangerment and environmental 
safety when it should be required.



Regards,



Dr. Ron Ney



----- Original Message ----- 
From: <pharmwaste-request at lists.dep.state.fl.us>
To: <pharmwaste at lists.dep.state.fl.us>
Sent: Friday, August 14, 2009 7:38 AM
Subject: Pharmwaste Digest, Vol 46, Issue 22


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> Today's Topics:
>
>   1. RE: (no subject) (Charlotte A. Smith)
>   2. RE: mixtures (Charlotte A. Smith)
>   3. FW: What you don't know can't hurt you, right? (Gilliam, Allen)
>


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