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<p class=MsoNormal><font size=2 color=navy face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:navy'>For those interested in the issue of
re-dispensing…It has taken me a while, but I think this means there is a
new complication. It would appear that repackaging medicine through blister
pack technology is not acceptable except for one, the first and initial, pass
to the first customer.<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 color=navy face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:navy'>It is not clear to me how any recycling
can then be done, unless original packaging is used.<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 color=navy face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:navy'>Stevan Gressitt, M.D. <o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 color=navy face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:navy'>207-441-0291<o:p></o:p></span></font></p>
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<p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><b><font size=2
face=Tahoma><span style='font-size:10.0pt;font-family:Tahoma;font-weight:bold'>From:</span></font></b><font
size=2 face=Tahoma><span style='font-size:10.0pt;font-family:Tahoma'> Claudia
Okeke [mailto:cco@usp.org] <br>
<b><span style='font-weight:bold'>Sent:</span></b> Friday, February 03, 2006
1:54 PM<br>
<b><span style='font-weight:bold'>Cc:</span></b> Claudia Okeke<br>
<b><span style='font-weight:bold'>Subject:</span></b> Can folks please clarify
the question on blister packs?</span></font><o:p></o:p></p>
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<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'><o:p> </o:p></span></font></p>
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<p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><font size=3
face=Tahoma><span style='font-size:12.0pt;font-family:Tahoma'>Dear Dr. Stevan,<o:p></o:p></span></font></p>
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<p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><font size=3
face=Tahoma><span style='font-size:12.0pt;font-family:Tahoma'>The content of
your discussion lies on two USP general chapters- <661> Containers, and
<1146> Repackaging in single dose containers such as blister packs. USP
says in <661> that reprocessing of repackaged unit dose container shall
not be done. Part of the concern here is on the the effect of heat sealing when
blistering, and the dosage form storage and handling which may compromise the
intergrity of the drug prior to adminstration. I hope this has answered your
question. <br>
Sincerely,<o:p></o:p></span></font></p>
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<p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><font size=3
face=Tahoma><span style='font-size:12.0pt;font-family:Tahoma'> <o:p></o:p></span></font></p>
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<p class=MsoNormal style='mso-margin-top-alt:0in;margin-right:0in;margin-bottom:
12.0pt;margin-left:0in'><font size=3 face=Tahoma><span style='font-size:12.0pt;
font-family:Tahoma'>Claudia C. Okeke, Ph.D.<br>
<br>
<o:p></o:p></span></font></p>
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