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<p class=MsoNormal><font size=2 color=navy face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:navy'>Physostigmine is often used in the
operation room. No, it does not have a low pH. Acutely hazardous wastes
(P-listed) have an LD50 of 50mg/kg or less. (oral LD 50 is the dose per kg that
kills half the lab animals when administered orally, usually mice or rats. The
lower the LD50, the more toxic.) That is, they are considered acutely toxic.
There is no correlation between corrosivity and acute toxicity. They are two
very different and separate definitions of hazardous waste.<o:p></o:p></span></font></p>
<div>
<p class=MsoNormal><font size=2 color=navy face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:navy'>Best regards,</span></font><font
color=navy><span style='color:navy'><o:p></o:p></span></font></p>
<p class=MsoNormal><st1:PersonName w:st="on"><font size=2 color=navy
face=Arial><span style='font-size:10.0pt;font-family:Arial;color:navy'>Charlotte
A. Smith</span></font></st1:PersonName><font size=2 color=navy face=Arial><span
style='font-size:10.0pt;font-family:Arial;color:navy'>, R. Ph., M.S., HEM</span></font><font
color=navy><span style='color:navy'><o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 color=navy face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:navy'>President</span></font><font color=navy><span
style='color:navy'><o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 color=navy face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:navy'>PharmEcology Associates, LLC</span></font><font
color=navy><span style='color:navy'><o:p></o:p></span></font></p>
<p class=MsoNormal><st1:Street w:st="on"><st1:address w:st="on"><font size=2
color=navy face=Arial><span style='font-size:10.0pt;font-family:Arial;
color:navy'>12229 W. North Ave., Suite 2</span></font></st1:address></st1:Street><font
color=navy><span style='color:navy'><o:p></o:p></span></font></p>
<p class=MsoNormal><st1:place w:st="on"><st1:City w:st="on"><font size=2
color=navy face=Arial><span style='font-size:10.0pt;font-family:Arial;
color:navy'>Wauwatosa</span></font></st1:City><font size=2 color=navy
face=Arial><span style='font-size:10.0pt;font-family:Arial;color:navy'>, <st1:State
w:st="on">WI</st1:State> <st1:PostalCode w:st="on">53226</st1:PostalCode></span></font></st1:place><font
color=navy><span style='color:navy'><o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 color=navy face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:navy'>414-292-3959</span></font><font
color=navy><span style='color:navy'><o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 color=navy face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:navy'>414-915-4026 (cell)</span></font><font
color=navy><span style='color:navy'><o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 color=navy face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:navy'><a href="mailto:csmith@pharmecology.com">csmith@pharmecology.com</a></span></font><font
color=navy><span style='color:navy'><o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 color=navy face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:navy'>www.pharmecology.com</span></font><o:p></o:p></p>
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<p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><b><font size=2
face=Tahoma><span style='font-size:10.0pt;font-family:Tahoma;font-weight:bold'>From:</span></font></b><font
size=2 face=Tahoma><span style='font-size:10.0pt;font-family:Tahoma'>
pharmwaste-bounces@lists.dep.state.fl.us
[mailto:pharmwaste-bounces@lists.dep.state.fl.us] <b><span style='font-weight:
bold'>On Behalf Of </span></b>William More<br>
<b><span style='font-weight:bold'>Sent:</span></b> Tuesday, October 14, 2008
2:35 PM<br>
<b><span style='font-weight:bold'>To:</span></b>
pharmwaste@lists.dep.state.fl.us<br>
<b><span style='font-weight:bold'>Subject:</span></b> [Pharmwaste] Re:
Pharmwaste Digest, Vol 36, Issue 11</span></font><o:p></o:p></p>
</div>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'><o:p> </o:p></span></font></p>
<div>
<p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><font size=2
face=Tahoma><span style='font-size:10.0pt;font-family:Tahoma'>How often do you
see Physostigmine Salicylate (P188)? Are you saying it is also a D002 as
it has a low pH?<o:p></o:p></span></font></p>
</div>
<div>
<p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><font size=2
face=Tahoma><span style='font-size:10.0pt;font-family:Tahoma'><br>
>>> <pharmwaste-request@lists.dep.state.fl.us> 10/14/08 2:53 PM
>>><br>
Send Pharmwaste mailing list submissions to<br>
pharmwaste@lists.dep.state.fl.us<br>
<br>
To subscribe or unsubscribe via the World Wide Web, visit<br>
<a href="http://lists.dep.state.fl.us/cgi">http://lists.dep.state.fl.us/cgi</a>-bin/mailman/listinfo/pharmwaste<br>
or, via email, send a message with subject or body 'help' to<br>
pharmwaste-request@lists.dep.state.fl.us<br>
<br>
You can reach the person managing the list at<br>
pharmwaste-owner@lists.dep.state.fl.us<br>
<br>
When replying, please edit your Subject line so it is more specific<br>
than "Re: Contents of Pharmwaste digest..."<br>
<br>
<br>
Today's Topics:<br>
<br>
1. RE: Pharmaceutical Corrosives (Jeff Hollar)<br>
2. FW: Sample prescription drugs (Tenace, Laurie)<br>
<br>
<br>
----------------------------------------------------------------------<br>
<br>
Message: 1<br>
Date: Tue, 14 Oct 2008 11:57:29 -0500<br>
From: "Jeff Hollar" <jhollar@pwaste.com><br>
Subject: RE: [Pharmwaste] Pharmaceutical Corrosives<br>
To: "'Sue Dayton'" <sdayton@swcp.com>,<br>
<pharmwaste@lists.dep.state.fl.us><br>
Cc: 'Carolyn Cole' <comet2000@nc.rr.com><br>
Message-ID: <006d01c92e1d$f3364840$d9a2d8c0$@com><br>
Content-Type: text/plain; charset="us-ascii"<br>
<br>
Sue,<br>
<br>
<br>
<br>
In our Waste-ID software, we classify pharmaceutical waste as a hazardous<br>
corrosive (D002, yes D002) if it has a pH of less than or equal to 2 or<br>
greater than or equal to<br>
<br>
12.5 (40 CFR Part 261.22). An example of an acutely hazardous liquid<br>
pharmaceutical waste would be Physostigmine Salicylate (P188), as it is a<br>
P-Listed waste. P-listed wastes are<br>
<br>
commercial chemical products which are classified as acutely hazardous under<br>
RCRA.<br>
<br>
<br>
<br>
Jeff Hollar<br>
<br>
President<br>
<br>
<br>
<br>
PharmWaste Technologies, Inc.<br>
<br>
<st1:Street w:st="on"><st1:address w:st="on">4164 NW Urbandale Dr.</st1:address></st1:Street>,
Suite A<br>
<br>
<st1:place w:st="on"><st1:City w:st="on">Urbandale</st1:City>, <st1:State
w:st="on">IA</st1:State> <st1:PostalCode w:st="on">50322</st1:PostalCode></st1:place><br>
<br>
(P) 515-276-5302 Ext. 316<br>
<br>
(F) 480-393-5564<br>
<br>
(E) Jhollar@Pwaste.com<br>
<br>
<br>
<br>
The unauthorized disclosure or interception of e-mail is a federal crime.<br>
See 18 U.S.C. SEC 2517(4). This e-mail is intended for the use of those whom<br>
it is addressed and may contain information that is privileged,<br>
confidential, and exempt from disclosure under the law. If you have received<br>
this e-mail in error, do not distribute or copy it. Please return it<br>
immediately to the sender with attachments, if any, and notify the sender by<br>
telephone.<br>
<br>
From: Sue Dayton [mailto:sdayton@swcp.com] <br>
Sent: Tuesday, October 14, 2008 10:10 AM<br>
To: 'Jeff Hollar'; pharmwaste@lists.dep.state.fl.us<br>
Cc: 'Carolyn Cole'<br>
Subject: RE: [Pharmwaste] Pharmaceutical Corrosives<br>
<br>
<br>
<br>
Hi Jeff:<br>
<br>
I have a question for you from a friend - do you know what is the ph level<br>
(or other factor) is for classifying such liquids and solutions as acutely<br>
hazardous vs. hazardous vs non-hazardous?<br>
<br>
Thank you!<br>
<br>
<br>
<br>
<br>
<br>
Sue Dayton<br>
<br>
Blue Ridge Environmental Defense League<br>
<br>
<st1:State w:st="on"><st1:place w:st="on">North Carolina</st1:place></st1:State>
Healthy Communities Program<br>
<br>
<st1:place w:st="on">PO</st1:place> <st1:address w:st="on"><st1:Street w:st="on">BOX</st1:Street>
44</st1:address><br>
<br>
<st1:place w:st="on"><st1:City w:st="on">Saxapahaw</st1:City>, <st1:State
w:st="on">NC</st1:State> <st1:PostalCode w:st="on">27340</st1:PostalCode></st1:place><br>
<br>
(336) 525-2003<br>
<br>
sdayton@swcp.com<br>
<br>
<br>
<br>
<br>
<br>
<br>
<br>
Our lives begin to end the day we become silent about things that matter.<br>
- Martin Luther King Jr.<br>
<br>
<br>
<br>
<br>
<br>
<br>
<br>
_____ <br>
<br>
From: pharmwaste-bounces@lists.dep.state.fl.us<br>
[mailto:pharmwaste-bounces@lists.dep.state.fl.us] On Behalf Of Jeff Hollar<br>
Sent: Tuesday, October 14, 2008 10:06 AM<br>
To: pharmwaste@lists.dep.state.fl.us<br>
Subject: [Pharmwaste] Pharmaceutical Corrosives<br>
<br>
<br>
<br>
I just posted this on the Practice Greenhealth listserve, but thought it<br>
would be beneficial to many of the members of this Pharmwaste listserve as<br>
well. <br>
<br>
<br>
<br>
Many of our hospital pharmacy customers are surprised to find out that their<br>
pharmaceutical inventory contains potentially corrosive waste other than a<br>
few compounding chemicals. One good example of this is Sporanox Solution
by<br>
JOM. A review of the package insert indicates a target pH of
2. We have<br>
performed internal tests and found the mode average pH to be closer to 1.
A<br>
liquid waste with a pH of 1 is considered corrosive waste by the EPA and<br>
carries an EPA waste code of D003. It is also considered corrosive when<br>
shipping by the DOT and carries a DOT shipping number of 8.<br>
<br>
We have found the pharmaceutical corrosive waste stream to be overlooked in<br>
many of the pharmaceutical inventories that we've analyzed. For those<br>
pharmacies performing their own waste identification analysis, I would<br>
encourage them to closely review the pH's of the liquids and solutions in<br>
their inventory. <br>
<br>
<br>
<br>
Jeff Hollar<br>
<br>
President<br>
<br>
PharmWaste Technologies, Inc.<br>
<br>
<st1:place w:st="on"><st1:City w:st="on">Urbandale</st1:City>, <st1:State
w:st="on">IA</st1:State> <st1:PostalCode w:st="on">50322</st1:PostalCode></st1:place><br>
<br>
Email: jhollar@pwaste.com<br>
<br>
Website: www.pwaste.com<br>
<br>
515-276-5302<br>
<br>
<br>
<br>
<br>
<br>
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<br>
Message: 2<br>
Date: Tue, 14 Oct 2008 14:52:17 -0400<br>
From: "Tenace, Laurie" <Laurie.Tenace@dep.state.fl.us><br>
Subject: [Pharmwaste] FW: Sample prescription drugs<br>
To: <pharmwaste@lists.dep.state.fl.us><br>
Cc: ayoungblut@cvmspc.com<br>
Message-ID:<br>
<21FA2802388E16418A98250FDEDB3FDEBFF40C@tlhexsmb5.floridadep.net><br>
Content-Type: text/plain; charset="us-ascii"<br>
<br>
Can anyone help this person?<br>
<br>
<br>
<br>
This question comes up a lot for me. A Florida Statute says, "All
out-of-date<br>
drug samples must be returned to the manufacturer or distributor of that drug<br>
sample." (<st1:country-region w:st="on"><st1:place w:st="on">Ch.</st1:place></st1:country-region>
499.028(9), F.S.) However every drug rep I've asked (just while<br>
waiting to see doctors at various times) has never heard this and insists<br>
that they do not take back samples. <br>
<br>
<br>
<br>
Thanks!<br>
<br>
Laurie<br>
<br>
<br>
<br>
Laurie J. Tenace<br>
Environmental Specialist<br>
Florida Department of Environmental Protection<br>
<st1:place w:st="on"><st1:City w:st="on">2600</st1:City> Blair Stone Road, <st1:State
w:st="on">MS</st1:State></st1:place> 4555<br>
<st1:place w:st="on"><st1:City w:st="on">Tallahassee</st1:City>, <st1:State
w:st="on">Florida</st1:State> <st1:PostalCode w:st="on">32399-2400</st1:PostalCode></st1:place><br>
PH: (850) 245-8759<br>
FAX: (850) 245-8811<br>
Laurie.Tenace@dep.state.fl.us <br>
<br>
Mercury web pages:<br>
<a href="http://www.dep.state.fl.us/waste/categories/mercury/default.htm">http://www.dep.state.fl.us/waste/categories/mercury/default.htm</a><br>
<<a href="http://www.dep.state.fl.us/waste/categories/mercury/default.htm">http://www.dep.state.fl.us/waste/categories/mercury/default.htm</a>>
<br>
<br>
Unwanted Medications web pages:<br>
<a href="http://www.dep.state.fl.us/waste/categories/medications/default.htm">http://www.dep.state.fl.us/waste/categories/medications/default.htm</a><br>
<<a
href="http://www.dep.state.fl.us/waste/categories/medications/default.htm">http://www.dep.state.fl.us/waste/categories/medications/default.htm</a>>
<br>
<br>
<br>
<br>
<br>
Please Note: <st1:State w:st="on"><st1:place w:st="on">Florida</st1:place></st1:State>
has a very broad public records law. Most written<br>
communications to or from state officials regarding state business are public<br>
records available to the public and media upon request. Your e-mail is<br>
communications and may therefore be subject to public disclosure.<br>
<br>
<br>
<br>
<br>
<br>
From: Angie Youngblut [mailto:AYoungblut@cvmspc.com] <br>
Sent: Tuesday, October 14, 2008 2:39 PM<br>
To: pharmwaste@lists.dep.state.fl.us<br>
Subject: FW: Sample prescription drugs<br>
<br>
<br>
<br>
I have been trying to get one clear answer- and haven't had much success. I<br>
have tried EPA, DNR, Iowa Board of Pharmacy, local landfill and others. I<br>
have expired sample prescription drugs to dispose of and I don't want to<br>
break any regulations, however I have been told I am a "waste generating<br>
facility" and therefore have different rules. It has been recommended to
me<br>
to mix them with undesirable substances and put in regular trash and that<br>
they are not considered hazardous.<br>
<br>
I do not have the option of giving them to a charitable organization because<br>
they will only take them( in the Iowa Drug Repository program) with a year<br>
left on the expiration and our offices keep them until they expire. <br>
<br>
Is there any clear guideline federally or in <st1:State w:st="on"><st1:place
w:st="on">Iowa</st1:place></st1:State> that I have missed? <br>
<br>
Angie Youngblut RN, BS <br>
Clinical <st1:place w:st="on"><st1:PlaceName w:st="on">Practice Manager</st1:PlaceName>
<br>
<st1:PlaceName w:st="on">Cedar</st1:PlaceName> <st1:PlaceType w:st="on">Valley</st1:PlaceType></st1:place>
Medical Specialists, P.C. <br>
4150 <st1:address w:st="on"><st1:Street w:st="on">Kimball Avenue</st1:Street> <br>
<st1:City w:st="on">Waterloo</st1:City>, <st1:State w:st="on">Iowa</st1:State> <st1:PostalCode
w:st="on">50701</st1:PostalCode></st1:address> <br>
Phone 319-235-5390 <br>
Fax 319-287-9249 <br>
ayoungblut@cvmspc.com<br>
<br>
<br>
<br>
The Department of Environmental <br>
<br>
Protection values your feedback as a customer. DEP Secretary Michael W. Sole is
committed to continuously assessing and <br>
<br>
improving the level and quality of services provided to you. Please take a few
minutes to comment on the quality of <br>
<br>
service you received. Copy the url below to a web browser to complete the DEP <br>
<br>
survey: <a
href="http://survey.dep.state.fl.us/?refemail=Laurie.Tenace@dep.state.fl.us">http://survey.dep.state.fl.us/?refemail=Laurie.Tenace@dep.state.fl.us</a>
Thank you in advance for completing the survey.<br>
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Pharmwaste@lists.dep.state.fl.us<br>
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<br>
<br>
End of Pharmwaste Digest, Vol 36, Issue 11<br>
******************************************<o:p></o:p></span></font></p>
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