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<p class=MsoNormal><font size=2 color=blue face=Arial><span style='font-size:
11.0pt;font-family:Arial;color:blue'>Jacob:<o:p></o:p></span></font></p>
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11.0pt;font-family:Arial;color:blue'><o:p> </o:p></span></font></p>
<p class=MsoNormal><font size=2 color=blue face=Arial><span style='font-size:
11.0pt;font-family:Arial;color:blue'>Can you tell me what happens to meperidine
(and what is it) after it is metabolized and released? Do you have any information
on the number of drugs that go through this same process that result in a more
toxic compound being released? <o:p></o:p></span></font></p>
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<p class=MsoNormal><font size=2 color=navy face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:navy'>Sue Dayton</span></font><font color=navy><span
style='color:navy'><o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 color=navy face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:navy'>Blue Ridge Environmental Defense League</span></font><font
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<p class=MsoNormal><st1:State w:st="on"><st1:place w:st="on"><font size=2
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color:navy'>North Carolina</span></font></st1:place></st1:State><font size=2
color=navy face=Arial><span style='font-size:10.0pt;font-family:Arial;
color:navy'> Healthy Communities Program</span></font><font color=navy><span
style='color:navy'><o:p></o:p></span></font></p>
<p class=MsoNormal><st1:place w:st="on"><font size=2 color=navy face=Arial><span
style='font-size:10.0pt;font-family:Arial;color:navy'>PO</span></font></st1:place><font
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color:navy'> <st1:address w:st="on"><st1:Street w:st="on">BOX</st1:Street> 44</st1:address></span></font><font
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face=Arial><span style='font-size:10.0pt;font-family:Arial;color:navy'>, <st1:State
w:st="on">NC</st1:State> <st1:PostalCode w:st="on">27340</st1:PostalCode></span></font></st1:place><font
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<p class=MsoNormal><font size=2 color=navy face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:navy'>(336) 525-2003</span></font><font
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10.0pt;font-family:Arial;color:navy'><a href="mailto:sdayton@swcp.com">sdayton@swcp.com</a></span></font><font
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become silent about things that matter. - Martin Luther King
Jr.<o:p></o:p></span></font></i></em></p>
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<p class=MsoNormal><b><font size=2 face=Tahoma><span style='font-size:10.0pt;
font-family:Tahoma;font-weight:bold'>From:</span></font></b><font size=2
face=Tahoma><span style='font-size:10.0pt;font-family:Tahoma'>
pharmwaste-bounces@lists.dep.state.fl.us
[mailto:pharmwaste-bounces@lists.dep.state.fl.us] <b><span style='font-weight:
bold'>On Behalf Of </span></b>Jacob Hutti<br>
<b><span style='font-weight:bold'>Sent:</span></b> Wednesday, February 10, 2010
11:11 AM<br>
<b><span style='font-weight:bold'>To:</span></b> Terri Buckner;
pharmwaste@lists.dep.state.fl.us<br>
<b><span style='font-weight:bold'>Subject:</span></b> RE: [Pharmwaste]
Excretion info: Aprepitant (Emend from Merck)</span></font><o:p></o:p></p>
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<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'><o:p> </o:p></span></font></p>
<p class=MsoNormal><font size=2 color=navy face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:navy'>NO. the other way around…. They
captured </span></font>57% recovered in urine and 45% in feces…
this only happens if a drug is removed unchanged from the body…<o:p></o:p></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'>A much more complicated question remains…what happens when a body
actually changes the drug and then excretes these other changed chemicals!!!
This is the problem with meperidine and hundreds of other drugs…. The
metabolite of meperidine is MUCH more toxic that the parent compound . <o:p></o:p></span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'><o:p> </o:p></span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'>Whether any drug is returned to the earth in any fashion the vast
majority that needs to be addressed is the volume that is taken or administered
or excreted in any form. It is absurd to try and address the miniscule % that
happens to go out of date on a shelf as a significant problem in the overall
view of biomass being returned to the earth.</span></font><font size=2
color=navy face=Arial><span style='font-size:10.0pt;font-family:Arial;
color:navy'><o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 color=navy face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:navy'><o:p> </o:p></span></font></p>
<div>
<p class=MsoNormal><font size=2 color=blue face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:blue'>Jacob Hutti, Pharm.D.</span></font><font
color=navy><span style='color:navy'><o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 color=blue face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:blue'>V.P. Business Development</span></font><font
color=navy><span style='color:navy'><o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 color=blue face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:blue'>PCA Pharmacy</span></font><font
color=navy><span style='color:navy'><o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 color=blue face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:blue'>1-866-213-8361</span></font><font
color=navy><span style='color:navy'><o:p></o:p></span></font></p>
<p class=MsoNormal><font size=3 color=navy face="Times New Roman"><span
style='font-size:12.0pt;color:navy'> <o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 color=navy face=Arial><span style='font-size:
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<p class=MsoNormal><b><font size=2 face=Tahoma><span style='font-size:10.0pt;
font-family:Tahoma;font-weight:bold'>From:</span></font></b><font size=2
face=Tahoma><span style='font-size:10.0pt;font-family:Tahoma'>
pharmwaste-bounces@lists.dep.state.fl.us
[mailto:pharmwaste-bounces@lists.dep.state.fl.us] <b><span style='font-weight:
bold'>On Behalf Of </span></b>Terri Buckner<br>
<b><span style='font-weight:bold'>Sent:</span></b> Wednesday, February 10, 2010
11:00 AM<br>
<b><span style='font-weight:bold'>To:</span></b>
pharmwaste@lists.dep.state.fl.us<br>
<b><span style='font-weight:bold'>Subject:</span></b> [Pharmwaste] Excretion
info: Aprepitant (Emend from Merck)</span></font><o:p></o:p></p>
</div>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'><o:p> </o:p></span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'>The patient info sheet, Metabolism section, from this drug says:<br>
<br>
Following administration of a single IV 100-mg dose of [14C]-aprepitant prodrug
to healthy subjects, 57% of the radioactivity was recovered in urine and 45% in
feces. A study was not conducted with radiolabeled capsule formulation.<br>
<br>
Does this mean that 43% is excreted in urine and 55% in feces?<br>
<br>
This is a drug used by cancer patients for nausea control. <o:p></o:p></span></font></p>
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