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<p class=MsoNormal><span style='font-size:11.0pt;color:#1F497D'>Forwarded from
a non-member.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;color:#1F497D'>Laurie<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;color:#1F497D'><o:p> </o:p></span></p>
<div style='border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0in 0in 0in'>
<p class=MsoNormal style='margin-left:.5in'><b><span style='font-size:10.0pt;
font-family:"Tahoma","sans-serif"'>From:</span></b><span style='font-size:10.0pt;
font-family:"Tahoma","sans-serif"'> j k [mailto:jameskallaos@gmail.com] <br>
<b>Sent:</b> Thursday, February 11, 2010 7:47 AM<br>
<b>To:</b> pharmwaste@lists.dep.state.fl.us<br>
<b>Subject:</b> Re: [Pharmwaste] Why are males disappearing in the human
population?<o:p></o:p></span></p>
</div>
<p class=MsoNormal style='margin-left:.5in'><o:p> </o:p></p>
<p class=MsoNormal style='margin-left:.5in'>Hi Sue and Pharmwaste,<br>
<br>
I posted this video to another listserve, with the negative response to it as
well:<br>
<a href="http://www.sciencebasedmedicine.org/?p=1122" target="_blank">http://www.sciencebasedmedicine.org/?p=1122</a><br>
<br>
The author is Harriet Hall, MD. I have no if she or the website is industry
sponsored, and have no idea where they get their<br>
funding. I looked but couldn't find anything about their<br>
financials...I always thought non-profits had to disclose that. But<br>
anyway...<br>
<br>
The author's argument debunking the documentary (and calling it irresponsible)
rests on an<br>
old school approach to EDCs through "toxicity" and linear<br>
dose-response.<br>
<br>
"The evidence is controversial. The first principle of toxicology is<br>
“the poison is in the dose.” (Hall:<br>
<a href="http://www.sciencebasedmedicine.org/?p=1122" target="_blank">http://www.sciencebasedmedicine.org/?p=1122</a>)<br>
<br>
I'm not a blog commenter, but it seems like a Pharmwaste response to this
pointing out that EDCs don't necessarily follow the traditional linear dose
response/ toxicity theory could be warranted. <br>
<br>
"Rather than linear dose-response curves, EDCs more often exert<br>
non-linear, sometimes U- or inverted U-shaped dose-response curves<br>
(4). Furthermore, there may be no ‘‘lowest observed adverse effect<br>
level’’, or LOAEL, of an environmental chemical in circumstances when<br>
any exposure is enough to exert a detectable effect (5). (Gore 2008.<br>
Why Endocrinologists Need to Take Ownership of Endocrine Disruption.<br>
Experimental Biology and Medicine. Volume 233, Number 1. P. 3.)<br>
<br>
"The immediate practical implication of these considerations is that<br>
it is potentially misleading to base environmental risk assessments<br>
solely on the results of short-term acute toxicity tests, on long-term<br>
tests which do not encompass the most sensitive part of an organism's<br>
life cycle (see Section 4), or on tests which fail properly to<br>
investigate low doses just below the traditionally-defined<br>
no-observed-effect-concentration (NOEC) or<o:p></o:p></p>
<div id=":2p">
<p class=MsoNormal style='mso-margin-top-alt:0in;margin-right:0in;margin-bottom:
12.0pt;margin-left:.5in'>no-observed-adverse-effect-level (NOAEL)."
(Matthiessen and Johnson<br>
2007. Implications of research on endocrine disruption for the<br>
environmental risk assessment, regulation and monitoring of chemicals<br>
in the European Union. Environmental Pollution. Volume 146, Issue 1,<br>
Pages 9-18)<br>
<br>
Any interest or suggestions?<br>
<br>
James Kallaos<br>
PhD Researcher<o:p></o:p></p>
</div>
<p class=MsoNormal style='mso-margin-top-alt:0in;margin-right:0in;margin-bottom:
12.0pt;margin-left:.5in'><o:p> </o:p></p>
<div>
<p class=MsoNormal style='margin-left:.5in'>On Wed, Feb 10, 2010 at 3:17 PM,
Sue Dayton <<a href="mailto:sdayton@swcp.com">sdayton@swcp.com</a>>
wrote:<o:p></o:p></p>
<div>
<div>
<p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
margin-left:.5in'><span style='font-size:10.0pt;font-family:"Arial","sans-serif";
color:black'><a href="http://organizations.plattsburgh.edu/biologyclub/"
target="_blank"
title="blocked::http://organizations.plattsburgh.edu/biologyclub/">http://organizations.plattsburgh.edu/biologyclub/</a></span><o:p></o:p></p>
<p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
margin-left:.5in'><span style='font-size:10.0pt;font-family:"Arial","sans-serif";
color:navy'> </span><o:p></o:p></p>
<p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
margin-left:.5in'><span style='font-size:10.0pt;font-family:"Arial","sans-serif";
color:navy'>Please take some time to watch this video. Educational,
fascinating, disturbing. </span><o:p></o:p></p>
<p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
margin-left:.5in'><span style='font-size:10.0pt;font-family:"Arial","sans-serif";
color:navy'> </span><o:p></o:p></p>
<p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
margin-left:.5in'><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'> </span><o:p></o:p></p>
<p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
margin-left:.5in'><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'> </span><o:p></o:p></p>
<p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
margin-left:.5in'><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'>Sue
Dayton</span><o:p></o:p></p>
<p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
margin-left:.5in'><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'>Blue
Ridge Environmental Defense League</span><o:p></o:p></p>
<p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
margin-left:.5in'><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'>North
Carolina Healthy Communities Program</span><o:p></o:p></p>
<p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
margin-left:.5in'><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'>PO
BOX 44</span><o:p></o:p></p>
<p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
margin-left:.5in'><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'>Saxapahaw,
NC 27340</span><o:p></o:p></p>
<p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
margin-left:.5in'><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'>(336)
525-2003</span><o:p></o:p></p>
<p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
margin-left:.5in'><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'><a
href="mailto:sdayton@swcp.com" target="_blank">sdayton@swcp.com</a></span><o:p></o:p></p>
<p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
margin-left:.5in'> <o:p></o:p></p>
<p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
margin-left:.5in'> <o:p></o:p></p>
<p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
margin-left:.5in'> <o:p></o:p></p>
<div>
<p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
margin-left:.5in'><i><span style='font-family:"Palatino Linotype","serif"'>Our
lives begin to end the day we become silent about things that
matter. - Martin Luther King Jr.</span></i><o:p></o:p></p>
<p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
margin-left:.5in'><span style='font-family:"Arial","sans-serif"'> </span><o:p></o:p></p>
</div>
<p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
margin-left:.5in'> <o:p></o:p></p>
<p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
margin-left:.5in'> <o:p></o:p></p>
<p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
margin-left:.5in'> <o:p></o:p></p>
</div>
</div>
<p class=MsoNormal style='mso-margin-top-alt:0in;margin-right:0in;margin-bottom:
12.0pt;margin-left:.5in'><br>
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