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<TITLE>High BPA levels don't swim well with sperm </TITLE>
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<P DIR=LTR><SPAN LANG="en-us"></SPAN><A HREF="http://www.msnbc.msn.com/id/39888170/ns/health-mens_health/"><SPAN LANG="en-us"></SPAN><SPAN LANG="en-us"><U><FONT COLOR="#0000FF" FACE="Times New Roman">http://www.msnbc.msn.com/id/39888170/ns/health-mens_health/</FONT></U></SPAN><SPAN LANG="en-us"></SPAN></A><SPAN LANG="en-us"></SPAN><SPAN LANG="en-us"></SPAN></P>
<P DIR=LTR><SPAN LANG="en-us"><B></B></SPAN><SPAN LANG="en-us"><B></B></SPAN><B><SPAN LANG="en"></SPAN><SPAN LANG="en"><FONT COLOR="#333333" SIZE=7 FACE="Georgia">High BPA levels don't swim well with sperm </FONT></SPAN></B></P>
<P DIR=LTR><SPAN LANG="en-us"><B></B></SPAN><SPAN LANG="en-us"><B></B></SPAN><B><SPAN LANG="en"></SPAN><SPAN LANG="en"><FONT COLOR="#333333" FACE="Arial">Food packaging chemical can reduce quality of semen, study finds </FONT></SPAN></B></P>
<P DIR=LTR><SPAN LANG="en-us"><B></B></SPAN><SPAN LANG="en-us"><B></B></SPAN><B><SPAN LANG="en"></SPAN><SPAN LANG="en"><FONT COLOR="#333333" FACE="Arial">By</FONT></SPAN></B><SPAN LANG="en-us"><B></B></SPAN><SPAN LANG="en-us"><B></B></SPAN><B><SPAN LANG="en"></SPAN><SPAN LANG="en"><FONT COLOR="#333333" FACE="Arial"></FONT></SPAN></B><SPAN LANG="en-us"><B></B></SPAN><SPAN LANG="en-us"><B></B></SPAN><B><SPAN LANG="en"></SPAN><SPAN LANG="en"> <FONT COLOR="#333333" FACE="Arial">Natasha Allen</FONT></SPAN></B><SPAN LANG="en-us"><B></B></SPAN><SPAN LANG="en-us"><B></B></SPAN><B><SPAN LANG="en"></SPAN><SPAN LANG="en"><FONT COLOR="#333333" FACE="Arial"></FONT></SPAN></B><SPAN LANG="en-us"></SPAN><SPAN LANG="en-us"></SPAN><SPAN LANG="en"> </SPAN></P>
<P DIR=LTR><SPAN LANG="en-us"></SPAN><SPAN LANG="en-us"></SPAN><SPAN LANG="en"></SPAN><SPAN LANG="en"><FONT COLOR="#333333" SIZE=2 FACE="Arial">LiveScience</FONT></SPAN><SPAN LANG="en-us"></SPAN><SPAN LANG="en-us"></SPAN><SPAN LANG="en"></SPAN><SPAN LANG="en"><FONT COLOR="#333333" SIZE=2 FACE="Arial"></FONT></SPAN><SPAN LANG="en-us"></SPAN><SPAN LANG="en-us"></SPAN><SPAN LANG="en"></SPAN><SPAN LANG="en-us"></SPAN><SPAN LANG="en-us"></SPAN><SPAN LANG="en"> </SPAN></P>
<P DIR=LTR><SPAN LANG="en-us"></SPAN><SPAN LANG="en-us"></SPAN><SPAN LANG="en"></SPAN><SPAN LANG="en"><FONT COLOR="#333333" SIZE=1 FACE="Arial">updated</FONT></SPAN><SPAN LANG="en-us"></SPAN><SPAN LANG="en-us"></SPAN><SPAN LANG="en"></SPAN><SPAN LANG="en"><FONT COLOR="#333333" SIZE=1 FACE="Arial"></FONT></SPAN><SPAN LANG="en-us"></SPAN><SPAN LANG="en-us"></SPAN><SPAN LANG="en"></SPAN><SPAN LANG="en"> <FONT COLOR="#333333" SIZE=1 FACE="Arial">10/28/2010 9:03:22 AM E</FONT></SPAN><SPAN LANG="en-us"></SPAN><SPAN LANG="en-us"></SPAN><SPAN LANG="en"></SPAN><SPAN LANG="en"><FONT COLOR="#333333" SIZE=1 FACE="Arial">T</FONT></SPAN><SPAN LANG="en-us"></SPAN><SPAN LANG="en-us"></SPAN><SPAN LANG="en"></SPAN><SPAN LANG="en"><FONT COLOR="#333333" SIZE=1 FACE="Arial"></FONT></SPAN><SPAN LANG="en-us"></SPAN><SPAN LANG="en-us"></SPAN><SPAN LANG="en"></SPAN><SPAN LANG="en"> <FONT COLOR="#333333" SIZE=1 FACE="Arial">2010-10-28T13:03:2</FONT></SPAN><SPAN LANG="en-us"></SPAN><SPAN LANG="en-us"></SPAN><SPAN LANG="en"></SPAN><SPAN LANG="en"><FONT COLOR="#333333" SIZE=1 FACE="Arial">2</FONT></SPAN><SPAN LANG="en-us"></SPAN><SPAN LANG="en-us"></SPAN><SPAN LANG="en"></SPAN><SPAN LANG="en"><FONT COLOR="#333333" SIZE=1 FACE="Arial"></FONT></SPAN><SPAN LANG="en-us"></SPAN><SPAN LANG="en-us"></SPAN><SPAN LANG="en"> </SPAN></P>
<P DIR=LTR><SPAN LANG="en-us"></SPAN><SPAN LANG="en-us"></SPAN><SPAN LANG="en"></SPAN><SPAN LANG="en"><FONT COLOR="#333333" FACE="Arial">Exposure</FONT></SPAN><SPAN LANG="en-us"></SPAN><SPAN LANG="en"></SPAN><SPAN LANG="en"> <FONT COLOR="#333333" FACE="Arial">to a chemical found in food packaging and other plastics,</FONT> <FONT COLOR="#333333" FACE="Arial">BPA, can reduce the quality of men's semen, according to the findings of a five-year study and one of the few involving humans rather than animal models. </FONT></SPAN></P>
<P DIR=LTR><SPAN LANG="en-us"></SPAN><SPAN LANG="en-us"></SPAN><SPAN LANG="en"></SPAN><SPAN LANG="en"><FONT COLOR="#333333" FACE="Arial">"This study counters the argument that only highly exposed populations are affected," said study auth</FONT><FONT COLOR="#333333" FACE="Arial">or Dr. De-Kun Li, a reproductive and perinatal epidemiologist at Kaiser Permanente's Division of Research in Oakland, Calif. </FONT></SPAN></P>
<P DIR=LTR><SPAN LANG="en"><FONT COLOR="#333333" FACE="Arial">"You can be exposed from the workplace. You can be exposed from consumer products. It doesn't really matter. Ultimately it will re</FONT><FONT COLOR="#333333" FACE="Arial">flect in your urine," he said.</FONT></SPAN><SPAN LANG="en-us"></SPAN><SPAN LANG="en"> </SPAN></P>
<P DIR=LTR><SPAN LANG="en-us"></SPAN><SPAN LANG="en"></SPAN><SPAN LANG="en"><FONT COLOR="#333333" FACE="Arial">The researchers suggest findings should apply to Americans since even low levels of</FONT></SPAN><SPAN LANG="en-us"> </SPAN><A HREF="http://www.livescience.com/health/090602-bad-plastic.html"><SPAN LANG="en-us"><U></U></SPAN><U><SPAN LANG="en"></SPAN></U><U><SPAN LANG="en"><FONT COLOR="#0000FF" FACE="Arial">BPA exposure</FONT></SPAN></U><SPAN LANG="en-us"></SPAN></A><SPAN LANG="en-us"></SPAN><SPAN LANG="en"></SPAN><SPAN LANG="en"><FONT COLOR="#333333" FACE="Arial">comparable to men in the general U.S. population</FONT><FONT COLOR="#333333" FACE="Arial"> were found to have an adverse effect on</FONT></SPAN><SPAN LANG="en-us"> </SPAN><A HREF="http://www.livescience.com/health/sperm-quality-test-100601.html"><SPAN LANG="en-us"><U></U></SPAN><U><SPAN LANG="en"></SPAN></U><U><SPAN LANG="en"><FONT COLOR="#0000FF" FACE="Arial">sperm quality</FONT></SPAN></U><SPAN LANG="en-us"></SPAN></A><SPAN LANG="en-us"></SPAN><SPAN LANG="en"></SPAN><SPAN LANG="en"><FONT COLOR="#333333" FACE="Arial"> and quantity.</FONT></SPAN></P>
<P DIR=LTR><SPAN LANG="en-us"><B></B></SPAN><B><SPAN LANG="en"></SPAN><SPAN LANG="en"><FONT COLOR="#333333" FACE="Arial">Urine BPA</FONT></SPAN></B><SPAN LANG="en-us"><B></B></SPAN><B><SPAN LANG="en"><BR>
</SPAN></B><SPAN LANG="en-us"></SPAN><SPAN LANG="en"></SPAN><SPAN LANG="en"><FONT COLOR="#333333" FACE="Arial">The study, based on measurements from 218 Chinese workers, found a link between high conc</FONT><FONT COLOR="#333333" FACE="Arial">entrations of BPA, or Bisphenol A, in men's urine and lower sperm counts, as well as poor-functioning sperm cells. </FONT></SPAN></P>
<P DIR=LTR><SPAN LANG="en"><FONT COLOR="#333333" FACE="Arial">The study began with 514 workers recruited from epoxy resin factories in China in 2004. Only 218 of the participants ended up submitting bo</FONT><FONT COLOR="#333333" FACE="Arial">th urine and semen specimens for the final assessment. Researchers measured semen quality by examining factors like concentration, vitality, motility (movement), total sperm count and morphology (size and shape).</FONT></SPAN><SPAN LANG="en-us"></SPAN><SPAN LANG="en"> </SPAN></P>
<P DIR=LTR><SPAN LANG="en-us"></SPAN><SPAN LANG="en"></SPAN><SPAN LANG="en"><FONT COLOR="#333333" FACE="Arial">Men exposed to BPA at work and who showed </FONT><FONT COLOR="#333333" FACE="Arial"> detectable urine BPA had more than three times the risk of lower sperm concentration and vitality than men with no detectable urine BPA. The former group also had more than four times the risk of lower sperm count and more than twice the risk of lower</FONT></SPAN><SPAN LANG="en-us"> </SPAN><A HREF="http://www.livescience.com/health/sperm-male-infertility-100204.html"><SPAN LANG="en-us"><U></U></SPAN><U><SPAN LANG="en"></SPAN></U><U><SPAN LANG="en"><FONT COLOR="#0000FF" FACE="Arial">sperm motility</FONT></SPAN></U><SPAN LANG="en-us"></SPAN></A><SPAN LANG="en-us"></SPAN><SPAN LANG="en"></SPAN><SPAN LANG="en"><FONT COLOR="#333333" FACE="Arial">. </FONT></SPAN></P>
<P DIR=LTR><SPAN LANG="en"><FONT COLOR="#333333" FACE="Arial">Li and his team discovered a similar association between men with low BPA exposure from environmental sources and raised urine BPA levels and decreased</FONT><FONT COLOR="#333333" FACE="Arial"> semen quality.</FONT></SPAN><SPAN LANG="en-us"></SPAN><SPAN LANG="en"> </SPAN></P>
<P DIR=LTR><SPAN LANG="en-us"></SPAN><A HREF="http://www.msnbc.msn.com/id/39760387/ns/health-men's_health?ns=health-mens_health"><SPAN LANG="en-us"><U></U></SPAN><U><SPAN LANG="en"></SPAN></U><U><SPAN LANG="en"><FONT COLOR="#0000FF" FACE="Arial">Story: Baldness drug works, but may cause sex problems</FONT></SPAN></U><SPAN LANG="en-us"></SPAN></A><SPAN LANG="en-us"></SPAN><SPAN LANG="en"> </SPAN></P>
<P DIR=LTR><SPAN LANG="en"><FONT COLOR="#333333" FACE="Arial">No correlation was shown between urine BPA and semen volume or shape.</FONT></SPAN><SPAN LANG="en-us"></SPAN><SPAN LANG="en"> </SPAN></P>
<P DIR=LTR><SPAN LANG="en-us"></SPAN><SPAN LANG="en"></SPAN><SPAN LANG="en"><FONT COLOR="#333333" FACE="Arial">Animal studies already have shown that BPA is a hormone disruptor that can affect male reproductive organs, including the epididymis (coiled structure in the scrotum) and testes. However, there have been few findings regarding the chemical</FONT><FONT COLOR="#333333" FACE="Arial">’</FONT><FONT COLOR="#333333" FACE="Arial">s influence on</FONT> <FONT COLOR="#333333" FACE="Arial">h</FONT><FONT COLOR="#333333" FACE="Arial">umans, including a recent study on</FONT></SPAN><SPAN LANG="en-us"> </SPAN><A HREF="http://www.livescience.com/health/male-menopause-100908.html"><SPAN LANG="en-us"><U></U></SPAN><U><SPAN LANG="en"></SPAN></U><U><SPAN LANG="en"><FONT COLOR="#0000FF" FACE="Arial">male sexual dysfunction</FONT></SPAN></U><SPAN LANG="en-us"></SPAN></A><SPAN LANG="en-us"></SPAN><SPAN LANG="en"></SPAN><SPAN LANG="en"> <FONT COLOR="#333333" FACE="Arial">by Li and his researchers. </FONT></SPAN></P>
<P DIR=LTR><SPAN LANG="en"><FONT COLOR="#333333" FACE="Arial">"Our study shows that BPA could lead to pathological changes to human organs</FONT> <FONT COLOR="#333333" FACE="Arial">—</FONT><FONT COLOR="#333333" FACE="Arial"> semen q</FONT><FONT COLOR="#333333" FACE="Arial">uality, in this case," Li told LiveScience. "In addition, this new finding of the detrimental effect of BPA exposure on semen quality raises the bar of BPA toxicity."</FONT></SPAN></P>
<P DIR=LTR><SPAN LANG="en-us"><B></B></SPAN><B><SPAN LANG="en"></SPAN><SPAN LANG="en"><FONT COLOR="#333333" FACE="Arial">How this affects Americans</FONT></SPAN></B><SPAN LANG="en-us"><B></B></SPAN><B><SPAN LANG="en"><BR>
</SPAN></B><SPAN LANG="en-us"></SPAN><SPAN LANG="en"></SPAN><SPAN LANG="en"><FONT COLOR="#333333" FACE="Arial">Bisphenol A can be found in food packaging (the primary sourc</FONT><FONT COLOR="#333333" FACE="Arial">e of human exposure), DVDs, paper coatings, and automotive equipment, among other products. Releases of the chemical to the environment exceed 1 million pounds per year, according to a recent report by the Environmental Protection Agency. </FONT></SPAN></P>
<P DIR=LTR><SPAN LANG="en"><FONT COLOR="#333333" FACE="Arial">Gail Prins, a r</FONT><FONT COLOR="#333333" FACE="Arial">eproductive physiologist at University of Illinois College of Medicine, who was not involved in the study, said the finding is important though unsurprising and that it emphasizes the importance of animal model research in predicting outcomes in human pop</FONT><FONT COLOR="#333333" FACE="Arial">u</FONT><FONT COLOR="#333333" FACE="Arial">lations.</FONT></SPAN><SPAN LANG="en-us"></SPAN><SPAN LANG="en"> </SPAN></P>
<P DIR=LTR><SPAN LANG="en-us"></SPAN><SPAN LANG="en"></SPAN><SPAN LANG="en"><FONT COLOR="#333333" FACE="Arial">"Evidence has indicated that for the past few decades, sperm counts have been declining in some human populations</FONT> <FONT COLOR="#333333" FACE="Arial">—</FONT><FONT COLOR="#333333" FACE="Arial"> and that this might be related to</FONT></SPAN><SPAN LANG="en-us"> </SPAN><A HREF="http://www.livescience.com/health/early-onset-puberty-girls-breast-cancer-100809.html"><SPAN LANG="en-us"><U></U></SPAN><U><SPAN LANG="en"></SPAN></U><U><SPAN LANG="en"><FONT COLOR="#0000FF" FACE="Arial">exposures to endocrine-disrupting chemicals</FONT></SPAN></U><SPAN LANG="en-us"></SPAN></A><SPAN LANG="en-us"></SPAN><SPAN LANG="en"></SPAN><SPAN LANG="en"> <FONT COLOR="#333333" FACE="Arial">such as BPA is very reasonable," Prins said. "I strongly believe that the U.S. should take measures to reduce the use of this chemical, since levels build over time." </FONT></SPAN></P>
<P DIR=LTR><SPAN LANG="en"><FONT COLOR="#333333" FACE="Arial">Current regulations should refle</FONT><FONT COLOR="#333333" FACE="Arial">ct more recent findings, said John Meeker, an assistant professor of environmental health sciences at the University of Michigan, who was not involved in Li's study. </FONT></SPAN></P>
<P DIR=LTR><SPAN LANG="en"><FONT COLOR="#333333" FACE="Arial">"We know that the majority of Americans have measurable levels of BPA in their bodies," M</FONT><FONT COLOR="#333333" FACE="Arial">eeker said. "Since new research results in both humans and animals are currently being published nearly every day, policies should be re-evaluated using the most up-to-date information available."</FONT></SPAN><SPAN LANG="en-us"></SPAN><SPAN LANG="en"> </SPAN></P>
<P DIR=LTR><SPAN LANG="en-us"></SPAN><SPAN LANG="en"></SPAN><SPAN LANG="en"><FONT COLOR="#333333" FACE="Arial">The findings suggest semen quality and male sexual dysfunction could be used as early indicators of for harmful BPA effects than other diseases, such as cancer, the r</FONT><FONT COLOR="#333333" FACE="Arial">esearchers say. </FONT></SPAN></P>
<P DIR=LTR><SPAN LANG="en"><FONT COLOR="#333333" FACE="Arial">Li and colleagues plan to examine the effects of BPA exposure during pregnancy. Though Li warned that further research is needed, he advised individuals to make informed decisions regarding products that may contain BPA. </FONT></SPAN></P>
<P DIR=LTR><SPAN LANG="en"><FONT COLOR="#333333" FACE="Arial">"As average consu</FONT><FONT COLOR="#333333" FACE="Arial">mers, we do not need to wait for regulatory agencies' decision. We can take precautionary steps to avoid the exposure to BPA in our daily life," he said. "Besides, there is no downside to avoiding BPA." </FONT></SPAN></P>
<P DIR=LTR><SPAN LANG="en"><FONT COLOR="#333333" FACE="Arial">The study was published in the Oct. 28 issue of the</FONT> <FONT COLOR="#333333" FACE="Arial">journal of Fertility and Sterility. The work was funded by the U.S. National Institute of Occupational Safety and Health.</FONT></SPAN><SPAN LANG="en-us"></SPAN><SPAN LANG="en"> </SPAN></P>
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