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<p class="MsoNormal"><span style="font-family:"Calibri","sans-serif";color:#0F243E">I am ccing some nongovernmental environmental activists on this email Wow, how depressing. Were most or all of these plants secondary plants? Were any tertiary? Are there
any ideas of nonprohibitive methods for reducing or eliminating the discharge of these pharmaceuticals into the receiving bodies? Would, in areas where there is the land, exposure to sunlight and ponds allow for the breakdown of these drugs (and how dangerous
might those products be)? Probably not possible in most urban areas and even where possible very costly.
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<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#0F243E">Diane D. Buxbaum, MPH<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#0F243E">Environmental Scientist<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#0F243E">U.S. Environmental Protection Agency,<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#0F243E">Region 2<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#0F243E">Division of Enforcement and Compliance Assistance<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#0F243E">290 Broadway (21 East)<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#0F243E">New York, NY 10007<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#0F243E">buxbaum.diane@epa.gov<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#0F243E">Phone 212-637-3919<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#0F243E">Fax 212-637-4086<o:p></o:p></span></p>
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<p class="MsoNormal"><b><span style="font-size:10.0pt;font-family:"Tahoma","sans-serif";color:windowtext">From:</span></b><span style="font-size:10.0pt;font-family:"Tahoma","sans-serif";color:windowtext"> pharmwaste-bounces@lists.dep.state.fl.us [mailto:pharmwaste-bounces@lists.dep.state.fl.us]
<b>On Behalf Of </b>DeBiasi, Deborah (DEQ)<br>
<b>Sent:</b> Tuesday, December 03, 2013 3:21 PM<br>
<b>To:</b> pharmwaste@lists.dep.state.fl.us<br>
<b>Subject:</b> [Pharmwaste] Concentrations of prioritized pharmaceuticals in effluents from 50 large wastewater treatment plants in the US and implications for risk estimation<o:p></o:p></span></p>
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<span style="font-size:15.5pt;color:black">Concentrations of prioritized pharmaceuticals in ef</span><span style="font-size:14.5pt;font-family:"Arial","sans-serif";color:black">fl</span><span style="font-size:15.5pt;color:black">uents from 50 large wastewater
treatment plants in the US and implications for risk estimation<o:p></o:p></span></p>
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<span style="color:black">Mitchell S. Kostich</span><sup><span style="font-family:"Arial","sans-serif";color:black">*</span></sup><span style="color:black">, Angela L. Batt, James M. Lazorchak<o:p></o:p></span></p>
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<b><i><span style="font-size:7.0pt;color:black">Ecological Exposure Research Division, National Exposure Research Laboratory, U.S. Environmental Protection Agency, 26 W. Martin Luther King Drive, Cincinnati, OH 45268, USA<o:p></o:p></span></i></b></p>
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<b><span style="color:black;letter-spacing:3.0pt">ABSTRACT<o:p></o:p></span></b></p>
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<!--[if gte vml 1]><v:line id="_x0000_s1026" style='position:absolute;left:0;text-align:left;z-index:251658240;mso-position-horizontal-relative:page;mso-position-vertical-relative:page' from="197.05pt,311.5pt" to="553.75pt,311.5pt" strokeweight=".7pt">
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measured concentrations of 56 active pharmaceutical ingredients (APIs) in effluent samples from 50 large wastewater treatment plants across the US. Hydrochlorothiazide was found in every sample. Metoprolol, atenolol, and carbamazepine were found in over 90%
of the samples. Valsartan had the highest concentration (5300 ng/L), and also had the highest average concentration (1600 ng/L) across all 50 samples. Estimates of potential risks to healthy human adults were greatest for six anti-hypertensive APIs (lisinopril,
hydrochlorothiazide, valsartan, atenolol, enalaprilat, and metoprolol), but nevertheless suggest risks of exposure to individual APIs as well as their mixtures are generally very low. Estimates of potential risks to aquatic life were also low for most APIs,
but suggest more detailed study of potential ecological impacts from four analytes (sertraline, propranolol, desmethylsertraline, and valsartan).<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="color:black;letter-spacing:-.4pt">Published by Elsevier Ltd.</span><o:p></o:p></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;color:navy">Deborah L. DeBiasi</span><span style="font-size:11.0pt;color:navy"><br>
</span><b><span style="font-size:10.0pt;color:navy">Email: <a href="mailto:Deborah.DeBiasi@deq.virginia.gov">Deborah.DeBiasi@deq.virginia.gov</a></span></b><b><i><span style="font-size:10.0pt;color:red"><br>
</span></i></b><span style="font-size:10.0pt;color:navy">WEB site address: <a href="http://www.deq.virginia.gov/">
www.deq.virginia.gov</a></span><span style="font-size:11.0pt;color:navy"><br>
</span><span style="font-size:10.0pt;color:navy">Virginia Department of Environmental Quality</span><span style="font-size:11.0pt;color:navy"><br>
</span><span style="font-size:10.0pt;color:navy">Office of Water Permits </span><span style="font-size:11.0pt;color:navy"><br>
</span><span style="font-size:10.0pt;color:navy">Industrial Pretreatment/Whole Effluent Toxicity (WET) Program</span><span style="font-size:11.0pt;color:navy"><br>
</span><span style="font-size:10.0pt;color:navy">PPCPs, EDCs, and Microconstituents<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;color:navy"><a href="http://www.deq.virginia.gov/Programs/Water/PermittingCompliance/PollutionDischargeElimination/Microconstituents.aspx">http://www.deq.virginia.gov/Programs/Water/PermittingCompliance/PollutionDischargeElimination/Microconstituents.aspx</a></span><span style="font-size:10.0pt;color:navy"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;color:navy">Mail: P.O. Box 1105, Richmond, VA 23218</span><span style="font-size:11.0pt;color:navy"><br>
</span><span style="font-size:10.0pt;color:navy">Location: 629 E. Main Street, Richmond, VA 23219</span><span style="font-size:11.0pt;color:navy"><br>
</span><span style="font-size:10.0pt;color:navy">PH: 804-698-4028 FAX: 804-698-4032<o:p></o:p></span></p>
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