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<p class="MsoNormal"><font size="3" color="#000099" face="Times New Roman"><span style="font-size:12.0pt"><a href="http://www.sciencedaily.com/releases/2014/05/140512101410.htm">http://www.sciencedaily.com/releases/2014/05/140512101410.htm</a></span><o:p></o:p></font></p>
<p class="MsoNormal"><font size="3" color="#000099" face="Times New Roman"><o:p> </o:p></font></p>
<p class="MsoNormal" style="background:white"><b><font size="3" color="#004276" face="Helvetica"><span style="font-size:12.0pt;font-family:"Helvetica","sans-serif";color:#004276;font-weight:bold">Endocrine disruptors impair human sperm function, research finds<o:p></o:p></span></font></b></p>
<p class="MsoNormal" align="right" style="text-align:right;background:white"><b><i><font size="1" color="#666666" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#666666;font-weight:bold;font-style:italic">Date:<o:p></o:p></span></font></i></b></p>
<p class="MsoNormal" style="background:white"><font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809">May 12, 2014<o:p></o:p></span></font></p>
<p class="MsoNormal" align="right" style="text-align:right;background:white"><b><i><font size="1" color="#666666" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#666666;font-weight:bold;font-style:italic">Source:<o:p></o:p></span></font></i></b></p>
<p class="MsoNormal" style="background:white"><font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809">EMBO - excellence in life sciences<o:p></o:p></span></font></p>
<p class="MsoNormal" align="right" style="text-align:right;background:white"><b><i><font size="1" color="#666666" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#666666;font-weight:bold;font-style:italic">Summary:<o:p></o:p></span></font></i></b></p>
<p class="MsoNormal" style="background:white"><font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809">A plethora of endocrine-disrupting chemicals interfere with human sperm function in
a way that may have a negative impact on fertilization, according to new research. The work suggests that endocrine disruptors may contribute to widespread fertility problems in the Western world in a way that hitherto has not been recognized.<o:p></o:p></span></font></p>
<p class="MsoNormal" style="background:white"><b><font size="1" color="#2b2e34" face="Helvetica"><span style="font-size:8.5pt;font-family:"Helvetica","sans-serif";color:#2B2E34;font-weight:bold">Share This<o:p></o:p></span></font></b></p>
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<font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809"><img border="0" width="200" height="300" id="Picture_x0020_3" src="cid:image001.jpg@01CF6DEF.64CF1CE0" alt="http://images.sciencedaily.com/2014/05/140512101410-large.jpg"></span></font><font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809"><o:p></o:p></span></font></p>
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<font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809">Illustration of sperm (stock image). A plethora of endocrine-disrupting chemicals interfere with human sperm function in a way that
may have a negative impact on fertilization.<o:p></o:p></span></font></p>
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<i><font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809;font-style:italic">Credit: © idambeer / Fotolia</span></font></i><font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809"><o:p></o:p></span></font></p>
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<font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809"><a href="javascript:void(0)"><font color="#004276"><span style="color:#004276;text-decoration:none">[Click to enlarge image]</span></font></a><o:p></o:p></span></font></p>
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<font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809;display:none">Illustration of sperm (stock image). A plethora of endocrine-disrupting chemicals interfere with human sperm function
in a way that may have a negative impact on fertilization.<o:p></o:p></span></font></p>
<p class="MsoNormal" align="right" style="mso-margin-top-alt:0in;margin-right:0in;margin-bottom:3.0pt;margin-left:3.0pt;text-align:right;background:#F2F3F4">
<i><font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809;display:none;font-style:italic">Credit: © idambeer / Fotolia</span></font></i><font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809;display:none"><o:p></o:p></span></font></p>
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<font size="1" color="#070809" face="Helvetica"><span style="font-size:9.0pt;font-family:"Helvetica","sans-serif";color:#070809">A plethora of endocrine-disrupting chemicals interfere with human sperm function in a way that may have a negative impact on fertilization.
These are the findings of a German -- Danish team of researchers from the Center of Advanced European Studies and Research in Bonn, Germany, and the University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark. The work, which is published
in </span></font><i><font size="1" color="#070809" face="Helvetica"><span style="font-size:9.0pt;font-family:"Helvetica","sans-serif";color:#070809;font-style:italic">EMBO reports</span></font></i><font size="1" color="#070809" face="Helvetica"><span style="font-size:9.0pt;font-family:"Helvetica","sans-serif";color:#070809">,
suggests that endocrine disruptors may contribute to widespread fertility problems in the Western world in a way that hitherto has not been recognized.<o:p></o:p></span></font></p>
<p class="MsoNormal" style="background:white"><font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809">Endocrine disruptors are present in food, textiles, drugs, household, and personal-care
products such as plastic bottles, toys, and cosmetics. Proving the deleterious effects of endocrine disruptors on human beings has been difficult due to a lack of suitable experimental systems.<o:p></o:p></span></font></p>
<p class="MsoNormal" style="background:white"><font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809"><o:p> </o:p></span></font></p>
<p class="MsoNormal" style="background:white"><font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809">The European Commission is currently reviewing its policy on endocrine-disrupting
chemicals. Last year, their plans caused a debate between endocrinologists and a group of toxicologists over how to regulate these chemicals. "Our study provides scientific evidence to assist forming international rules and practices," said the leader of the
study, Timo Strünker, from the Center of Advanced European Studies and Research in Bonn, Germany.<o:p></o:p></span></font></p>
<p class="MsoNormal" style="background:white"><font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809"><o:p> </o:p></span></font></p>
<p class="MsoNormal" style="background:white"><font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809">"For the first time, we have shown a direct link between exposure to endocrine disrupting
chemicals from industrial products and adverse effects on human sperm function,'' said Niels E. Skakkebaek, professor and leader of the Danish team.<o:p></o:p></span></font></p>
<p class="MsoNormal" style="background:white"><font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809"><o:p> </o:p></span></font></p>
<p class="MsoNormal" style="background:white"><font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809">Hundreds to thousands of chemicals can be rapidly tested for their potential to interfere
with human sperm function using the bioassay developed by the researchers. In this initial study, about one hundred chemicals were tested. Around one third, including ultraviolet (UV) filters like 4-methylbenzylidene camphor (4-MBC) used in some sunscreens,
the anti-bacterial agent Triclosan used in toothpaste, and di-<i><span style="font-style:italic">n</span></i>-butylphthalate (DnBP), showed adverse actions.<o:p></o:p></span></font></p>
<p class="MsoNormal" style="background:white"><font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809"><o:p> </o:p></span></font></p>
<p class="MsoNormal" style="background:white"><font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809">The scientists looked at the impact of these chemicals on the CatSper ion channel,
a calcium channel controlling sperm motility. They showed that endocrine disruptors -- applied at concentrations measured in body fluids -- directly open CatSper and, thereby, increase calcium levels in sperm, change their swimming behavior, and trigger the
release of digestive enzymes that help sperm to break through the egg coat. Moreover, endocrine disruptors render sperm less sensitive for progesterone and prostaglandins -- two important hormones released by cells surrounding the egg. Finally, the authors
noted that in low-dose mixtures, the chemicals cooperate to elevate calcium levels in sperm.<o:p></o:p></span></font></p>
<p class="MsoNormal" style="background:white"><font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809"><o:p> </o:p></span></font></p>
<p class="MsoNormal" style="background:white"><font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809">Altogether, the study indicates that endocrine disruptors might disturb the precisely
coordinated sequence of events underlying fertilization in several ways: the chemicals might evoke changes in swimming behaviour at the wrong time and wrong place, hinder navigation of sperm towards the egg, and hamper penetration into the protective egg coat.<o:p></o:p></span></font></p>
<p class="MsoNormal" style="background:white"><font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809"><o:p> </o:p></span></font></p>
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<p class="MsoNormal" style="background:white"><b><font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809;font-weight:bold">Story Source:</span></font></b><font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809"><o:p></o:p></span></font></p>
<p class="MsoNormal" style="background:white"><font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809">The above story is based on
<a href="http://www.embo.org/news/research-news/research-news-2014/endocrine-disruptors-impair-human-sperm-function" target="_blank">
<font color="#004276"><span style="color:#004276;text-decoration:none">materials</span></font></a> provided by
<a href="http://www.embo.org" target="_blank"><b><font color="#004276"><span style="color:#004276;font-weight:bold;text-decoration:none">EMBO - excellence in life sciences</span></font></b></a>.
<i><span style="font-style:italic">Note: Materials may be edited for content and length.</span></i><o:p></o:p></span></font></p>
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<p class="MsoNormal" style="background:white"><b><font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809;font-weight:bold">Journal Reference</span></font></b><font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809">:<o:p></o:p></span></font></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:13.8pt;text-indent:-.25in;mso-list:l2 level1 lfo2;background:white">
<![if !supportLists]><font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809"><span style="mso-list:Ignore">1.<font size="1" face="Times New Roman"><span style="font:7.0pt "Times New Roman"">
</span></font></span></span></font><![endif]><font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809">Schiffer C, Müller A, Egeberg DL, Brenker C, Rehfeld A, Frederiksen H, Wäschle B, Kaupp
UB, Balbach M, Wachten D, Skakkebaek NE, Almstrup K, Strünker T. </span></font><b><font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809;font-weight:bold">Direct action of endocrine disrupting
chemicals on human sperm</span></font></b><font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809">.
</span></font><i><font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809;font-style:italic">EMBOreports</span></font></i><font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809">,
2014 DOI: <a href="http://dx.doi.org/10.15252/embr.201438869" target="_blank"><font color="#004276"><span style="color:#004276;text-decoration:none">10.15252/embr.201438869</span></font></a>
<o:p></o:p></span></font></p>
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</span></font></span></span></font><![endif]><font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809"><o:p> </o:p></span></font></p>
<p class="MsoNormal" style="background:#F2F3F4"><font size="1" color="#070809" face="Helvetica"><span style="font-size:8.0pt;font-family:"Helvetica","sans-serif";color:#070809">EMBO - excellence in life sciences. "Endocrine disruptors impair human sperm function,
research finds." ScienceDaily. ScienceDaily, 12 May 2014. <www.sciencedaily.com/releases/2014/05/140512101410.htm>.<o:p></o:p></span></font></p>
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<p class="MsoNormal"><font size="2" color="navy" face="Times New Roman"><span style="font-size:10.0pt;color:navy">Deborah L. DeBiasi</span></font><font size="2" color="navy"><span style="font-size:11.0pt;color:navy"><br>
</span></font><b><font size="2" color="navy"><span style="font-size:10.0pt;color:navy;font-weight:bold">Email: Deborah.DeBiasi@deq.virginia.gov</span></font></b><b><i><font size="2" color="red"><span style="font-size:10.0pt;color:red;font-weight:bold;font-style:italic"><br>
</span></font></i></b><font size="2" color="navy"><span style="font-size:10.0pt;color:navy">WEB site address:
<a href="http://www.deq.virginia.gov/">www.deq.virginia.gov</a></span></font><font size="2" color="navy"><span style="font-size:11.0pt;color:navy"><br>
</span></font><font size="2" color="navy"><span style="font-size:10.0pt;color:navy">Virginia Department of Environmental Quality</span></font><font size="2" color="navy"><span style="font-size:11.0pt;color:navy"><br>
</span></font><font size="2" color="navy"><span style="font-size:10.0pt;color:navy">Office of Water Permits
</span></font><font size="2" color="navy"><span style="font-size:11.0pt;color:navy"><br>
</span></font><font size="2" color="navy"><span style="font-size:10.0pt;color:navy">Industrial Pretreatment/Whole Effluent Toxicity (WET) Program</span></font><font size="2" color="navy"><span style="font-size:11.0pt;color:navy"><br>
</span></font><font size="2" color="navy"><span style="font-size:10.0pt;color:navy">PPCPs, EDCs, and Microconstituents<o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" color="navy" face="Times New Roman"><span style="font-size:11.0pt;color:navy"><a href="http://www.deq.virginia.gov/Programs/Water/PermittingCompliance/PollutionDischargeElimination/Microconstituents.aspx">http://www.deq.virginia.gov/Programs/Water/PermittingCompliance/PollutionDischargeElimination/Microconstituents.aspx</a></span></font><font size="2" color="navy"><span style="font-size:10.0pt;color:navy"><o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" color="navy" face="Times New Roman"><span style="font-size:10.0pt;color:navy">Mail: P.O. Box 1105, Richmond, VA 23218</span></font><font size="2" color="navy"><span style="font-size:11.0pt;color:navy"><br>
</span></font><font size="2" color="navy"><span style="font-size:10.0pt;color:navy">Location: 629 E. Main Street, Richmond, VA 23219</span></font><font size="2" color="navy"><span style="font-size:11.0pt;color:navy"><br>
</span></font><font size="2" color="navy"><span style="font-size:10.0pt;color:navy">PH: 804-698-4028 FAX: 804-698-4032<o:p></o:p></span></font></p>
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