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</o:shapelayout></xml><![endif]--></head><body lang=EN-US link=blue vlink=purple><div class=WordSection1><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Ron, you should read the attached study done by a division of Deloitte in Paris. There are over 500 references.<o:p></o:p></span></p><p class=MsoListParagraph style='text-indent:-.25in;mso-list:l0 level1 lfo1'><![if !supportLists]><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><span style='mso-list:Ignore'>1.<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>As far as your question on excreted drugs and metabolites that information comes from the FDA on every drug, check the next time you get a prescription, it will tell you how much comes out in the urine and feces and how quickly.<o:p></o:p></span></p><p class=MsoListParagraph style='text-indent:-.25in;mso-list:l0 level1 lfo1'><![if !supportLists]><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><span style='mso-list:Ignore'>2.<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Degradation of Cyclophosphamide and Ifosphamide have been studied extensively as well as other chemotherapy drugs. The EU study covers that and can dig those out for you.<o:p></o:p></span></p><p class=MsoListParagraph style='text-indent:-.25in;mso-list:l0 level1 lfo1'><![if !supportLists]><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><span style='mso-list:Ignore'>3.<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>There are many studies that show cyclophosphamide (U058) and Acrolein (P003) the main metabolite in the water (page 81 of the attached study)<o:p></o:p></span></p><p class=MsoListParagraph style='text-indent:-.25in;mso-list:l0 level1 lfo1'><![if !supportLists]><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><span style='mso-list:Ignore'>4.<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>I think in your last sentence you may be looking at drugs as persistent organic compounds, this is a problem because they are polar and completely water soluble. The EU report states exactly that and that current modeling does not work ( I take this as a statement that traditional toxicology modeling does not work for drugs)<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Hope that was helpful.<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Jim<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal><b><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'>From:</span></b><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'> pharmwaste-bounces@lists.dep.state.fl.us [mailto:pharmwaste-bounces@lists.dep.state.fl.us] <b>On Behalf Of </b>Ronald Ney<br><b>Sent:</b> Saturday, September 13, 2014 10:59 AM<br><b>To:</b> pharmwaste@lists.dep.state.fl.us<br><b>Subject:</b> [Pharmwaste] Re: Pharmwaste Digest, Vol 107, Issue 21<o:p></o:p></span></p><p class=MsoNormal><o:p> </o:p></p><div><p class=MsoNormal>I have yet to see data on metabolites secreted or degradation of parent and metabolites in the environment by photodegradation, pH, microbial degradation. Are there analytes for parent and degradation products? Have the extraction methods be proven that parent and degradates can be extracted over time and that they are not adsorbed in the media tested? <o:p></o:p></p><div><p class=MsoNormal><o:p> </o:p></p></div><div><p class=MsoNormal>Ron Ney<o:p></o:p></p></div></div><div><p class=MsoNormal><o:p> </o:p></p><div><p class=MsoNormal>On Sat, Sep 13, 2014 at 12:58 AM, <<a href="mailto:pharmwaste-request@lists.dep.state.fl.us" target="_blank">pharmwaste-request@lists.dep.state.fl.us</a>> wrote:<o:p></o:p></p><p class=MsoNormal>Send Pharmwaste mailing list submissions to<br> <a href="mailto:pharmwaste@lists.dep.state.fl.us">pharmwaste@lists.dep.state.fl.us</a><br><br>To subscribe or unsubscribe via the World Wide Web, visit<br> <a href="http://lists.dep.state.fl.us/cgi-bin/mailman/listinfo/pharmwaste" target="_blank">http://lists.dep.state.fl.us/cgi-bin/mailman/listinfo/pharmwaste</a><br>or, via email, send a message with subject or body 'help' to<br> <a href="mailto:pharmwaste-request@lists.dep.state.fl.us">pharmwaste-request@lists.dep.state.fl.us</a><br><br>You can reach the person managing the list at<br> <a href="mailto:pharmwaste-owner@lists.dep.state.fl.us">pharmwaste-owner@lists.dep.state.fl.us</a><br><br>When replying, please edit your Subject line so it is more specific<br>than "Re: Contents of Pharmwaste digest..."<br><br>Today's Topics:<br><br> 1. excreted drugs & whole effluent toxicity? (Gilliam, Allen)<br> 2. NIOSH Updates Hazardous Drug List 2014 (Jeff Hollar)<br> 3. RE: excreted drugs & whole effluent toxicity? (Jim Mullowney)<br><br><br>---------- Forwarded message ----------<br>From: "Gilliam, Allen" <<a href="mailto:GILLIAM@adeq.state.ar.us">GILLIAM@adeq.state.ar.us</a>><br>To: "'<a href="mailto:pharmwaste@lists.dep.state.fl.us">pharmwaste@lists.dep.state.fl.us</a>'" <<a href="mailto:pharmwaste@lists.dep.state.fl.us">pharmwaste@lists.dep.state.fl.us</a>><br>Cc: "<a href="mailto:Glassmeyer.susan@Epa.gov">Glassmeyer.susan@Epa.gov</a>" <<a href="mailto:Glassmeyer.susan@epa.gov">Glassmeyer.susan@epa.gov</a>><br>Date: Fri, 12 Sep 2014 09:40:31 -0500<br>Subject: [Pharmwaste] excreted drugs & whole effluent toxicity?<o:p></o:p></p><div><div><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'>Fellow Pharma folks,</span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'> </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'>Sorry for getting off the take-back programs for just a minute.</span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'> </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'>Maybe most of you have already seen this, but Dr. Christian Daughton recently authored this <u><span style='color:#262626'>Eco-directed sustainable prescribing: feasibility for reducing water contamination by drugs</span></u><span style='color:#1F497D'> @ </span><a href="http://dx.doi.org/10.1016/j.scitotenv.2014.06.013" target="_blank"><span style='color:#0563C1'>http://dx.doi.org/10.1016/j.scitotenv.2014.06.013</span></a> . Its abstract itself may take a few readings to understand (at least it did for me), but I believe the underlying concept of the manuscript is P2’s source reduction.</span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'> </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'>I only briefly scanned several pages of its content and is way above this mechanical engineer’s head. For those of you familiar with pharmacokinetics, you may be able to glean some important themes in the Dr’s contentions. </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'> </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'>Add another acronym to your vocabulary if you haven’t already because Biopharmaceutics Drug Disposition Classification System (BDDCS) runs throughout its core.</span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'> </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'>I would expect a brief synopsis from our dear friend, Dr. Charlotte Smith in a few weeks.</span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'> </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'>My original e-mail’s intent to several experts on this issue was mainly to discover which analytical methods could be used to measure low level APIs (which method measure what APIs or their metabolites?); therefore, helping to determine if their presence could potentially be the toxicant(s) in cities’ WET sublethality failures (growth and reproductivity). </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'> </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'>Dr. Susan Glassmeyer, e-cc’d above was suggested as a good source by Dr. Daughton. Dr. Glassmeyer? Would you please respond in some manner? I’d love for more cities to get involved with their own w.w. treatment plant’s effluent quality. Heretofore, most cities in the US are not sampling/analyzing for APIs or their metabolites. At least I have seen very few reports about them except through the USGS.</span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'> </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'>Ciao, </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'> </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'>Allen Gilliam</span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'>ADEQ State Pretreatment Coordinator</span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'><a href="tel:501.682.0625" target="_blank">501.682.0625</a></span><o:p></o:p></p></div></div><p class=MsoNormal><br><br>---------- Forwarded message ----------<br>From: Jeff Hollar <<a href="mailto:jhollar@pwaste.com">jhollar@pwaste.com</a>><br>To: <<a href="mailto:pharmwaste@lists.dep.state.fl.us">pharmwaste@lists.dep.state.fl.us</a>><br>Cc: <br>Date: Fri, 12 Sep 2014 10:43:21 -0500<br>Subject: [Pharmwaste] NIOSH Updates Hazardous Drug List 2014<o:p></o:p></p><div><div><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'>27 new drugs added and 12 drugs removed. We have incorporated these changes in our database.<o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'> <o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><a href="http://www.cdc.gov/niosh/docs/2014-138/pdfs/2014-138.pdf" target="_blank">http://www.cdc.gov/niosh/docs/2014-138/pdfs/2014-138.pdf</a><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'> <o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'>Jeff Hollar</span><o:p></o:p></p><div><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'>President</span><o:p></o:p></p></div><div><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><b><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif";color:navy'>PharmWaste Technologies, Inc.</span></b><o:p></o:p></p></div><div><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'>4164 NW Urbandale Dr., Ste A</span><o:p></o:p></p></div><div><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'>Urbandale, IA 50322</span><o:p></o:p></p></div><div><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'><a href="tel:515-276-5302" target="_blank">515-276-5302</a> (general)</span><o:p></o:p></p></div><div><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'><a href="tel:515-331-7310" target="_blank">515-331-7310</a> (direct)</span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'><a href="tel:515-360-9785" target="_blank">515-360-9785</a> (cell)</span><o:p></o:p></p></div><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif";color:blue'><a href="http://www.pwaste.com/" target="_blank" title="http://www.pwaste.com/">www.pwaste.com</a></span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'> <o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'> <o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'> <o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'> <o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'> <o:p></o:p></p></div></div><p class=MsoNormal><br><br>---------- Forwarded message ----------<br>From: Jim Mullowney <<a href="mailto:jmullowney@pharma-cycle.com">jmullowney@pharma-cycle.com</a>><br>To: "'Gilliam, Allen'" <<a href="mailto:GILLIAM@adeq.state.ar.us">GILLIAM@adeq.state.ar.us</a>>, <<a href="mailto:pharmwaste@lists.dep.state.fl.us">pharmwaste@lists.dep.state.fl.us</a>><br>Cc: <a href="mailto:Glassmeyer.susan@epa.gov">Glassmeyer.susan@epa.gov</a><br>Date: Fri, 12 Sep 2014 11:45:37 -0400<br>Subject: RE: [Pharmwaste] excreted drugs & whole effluent toxicity?<o:p></o:p></p><div><div><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='color:#1F497D'>What I took from Dr. Daughton’s report is that the way to reduce the effects of drugs in the environment is to lower the dose administered to the patient because drugs are in the environment from human excretion. </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='color:#1F497D'> </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='color:#1F497D'>He further states:</span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-autospace:none'> <o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:.5in;text-autospace:none'>“Certain drug classes (especially cytotoxic chemotherapeutics) may not be amenable to this approach; the best control measure for such highly toxic drugs may simply be the prevention of urine and feces from entering sewers”<o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='color:#1F497D'> </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='color:#1F497D'>There are 27 cytotoxic chemotherapy drugs that are heavily excreted (I attached the list) and need to be collected for 48 hours after infusion according to the World Health Organization. Go to <a href="http://www.cytotoxicsafety.com" target="_blank">www.cytotoxicsafety.com</a> to see how to easily control human waste with cytotoxic chemotherapy drugs.</span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='color:#1F497D'> </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='color:#1F497D'> </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='color:#1F497D'>Jim Mullowney</span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='color:#1F497D'> </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='color:#1F497D'> </span><o:p></o:p></p><div><div style='border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0in 0in 0in'><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><b><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'>From:</span></b><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'> <a href="mailto:pharmwaste-bounces@lists.dep.state.fl.us" target="_blank">pharmwaste-bounces@lists.dep.state.fl.us</a> [mailto:<a href="mailto:pharmwaste-bounces@lists.dep.state.fl.us" target="_blank">pharmwaste-bounces@lists.dep.state.fl.us</a>] <b>On Behalf Of </b>Gilliam, Allen<br><b>Sent:</b> Friday, September 12, 2014 10:41 AM<br><b>To:</b> '<a href="mailto:pharmwaste@lists.dep.state.fl.us" target="_blank">pharmwaste@lists.dep.state.fl.us</a>'<br><b>Cc:</b> <a href="mailto:Glassmeyer.susan@Epa.gov">Glassmeyer.susan@Epa.gov</a><br><b>Subject:</b> [Pharmwaste] excreted drugs & whole effluent toxicity?</span><o:p></o:p></p></div></div><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'> <o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'>Fellow Pharma folks,</span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'> </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'>Sorry for getting off the take-back programs for just a minute.</span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'> </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'>Maybe most of you have already seen this, but Dr. Christian Daughton recently authored this <u><span style='color:#262626'>Eco-directed sustainable prescribing: feasibility for reducing water contamination by drugs</span></u><span style='color:#1F497D'> @ </span><a href="http://dx.doi.org/10.1016/j.scitotenv.2014.06.013" target="_blank"><span style='color:#0563C1'>http://dx.doi.org/10.1016/j.scitotenv.2014.06.013</span></a> . Its abstract itself may take a few readings to understand (at least it did for me), but I believe the underlying concept of the manuscript is P2’s source reduction.</span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'> </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'>I only briefly scanned several pages of its content and is way above this mechanical engineer’s head. For those of you familiar with pharmacokinetics, you may be able to glean some important themes in the Dr’s contentions. </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'> </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'>Add another acronym to your vocabulary if you haven’t already because Biopharmaceutics Drug Disposition Classification System (BDDCS) runs throughout its core.</span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'> </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'>I would expect a brief synopsis from our dear friend, Dr. Charlotte Smith in a few weeks.</span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'> </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'>My original e-mail’s intent to several experts on this issue was mainly to discover which analytical methods could be used to measure low level APIs (which method measure what APIs or their metabolites?); therefore, helping to determine if their presence could potentially be the toxicant(s) in cities’ WET sublethality failures (growth and reproductivity). </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'> </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'>Dr. Susan Glassmeyer, e-cc’d above was suggested as a good source by Dr. Daughton. Dr. Glassmeyer? Would you please respond in some manner? I’d love for more cities to get involved with their own w.w. treatment plant’s effluent quality. Heretofore, most cities in the US are not sampling/analyzing for APIs or their metabolites. At least I have seen very few reports about them except through the USGS.</span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'> </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'>Ciao, </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'> </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'>Allen Gilliam</span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'>ADEQ State Pretreatment Coordinator</span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Arial","sans-serif"'><a href="tel:501.682.0625" target="_blank">501.682.0625</a></span><o:p></o:p></p></div></div><p class=MsoNormal style='margin-bottom:12.0pt'><br>---<br>Note: As a courtesy to other listserv subscribers, please post messages to the listserv in plain text format to avoid the garbling of messages received by digest recipients.<br>---<br>TO SUBSCRIBE, go to: <a href="http://lists.dep.state.fl.us/cgi-bin/mailman/listinfo/pharmwaste" target="_blank">http://lists.dep.state.fl.us/cgi-bin/mailman/listinfo/pharmwaste</a><br>TO UNSUBSCRIBE, DO NOT REPLY TO THE LISTSERV. Please send an e-mail to <a href="mailto:pharmwaste-unsubscribe@lists.dep.state.fl.us">pharmwaste-unsubscribe@lists.dep.state.fl.us</a> -- the subject line and body of the e-mail should be blank.<br>If you believe you may be subscribed with a different email address, please visit the subscriber listing at <a href="http://lists.dep.state.fl.us/cgi-bin/mailman/roster/pharmwaste" target="_blank">http://lists.dep.state.fl.us/cgi-bin/mailman/roster/pharmwaste</a><br>FOR PROBLEMS: Contact List Administrator <a href="mailto:Laurie.Tenace@dep.state.fl.us">Laurie.Tenace@dep.state.fl.us</a><br>SEND MAIL to the list server at: <a href="mailto:pharmwaste@lists.dep.state.fl.us">pharmwaste@lists.dep.state.fl.us</a><o:p></o:p></p></div><p class=MsoNormal><o:p> </o:p></p></div></div></body></html>