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</o:shapelayout></xml><![endif]--></head><body lang=EN-US link=blue vlink=purple><div class=WordSection1><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>I agree with Mitch except for Cytotoxic chemotherapy drugs and when I questioned his work in regards to Chemo this was his response:<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal style='margin-left:.5in'><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:windowtext'>“Hi Jim:<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:windowtext'><o:p> </o:p></span></p><p class=MsoNormal style='margin-left:.5in'><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:windowtext'>Thanks for your helpful comment. I do think genotoxic pharmaceuticals deserve special treatment, and will try and emphasize this point in future presentations. <o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:windowtext'><o:p> </o:p></span></p><p class=MsoNormal style='margin-left:.5in'><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:windowtext'>I did recognize the fact that equating daily doses of different pharmaceuticals regardless of endpoint was problematic (mentioning chemotherapy agents in particular), but should also point out that genotoxic drugs may not have a threshold effect level, and would probably be better evaluated using approaches similar to those used for estimating risks from low level radiation exposure.”<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:windowtext'><o:p> </o:p></span></p><p class=MsoNormal style='margin-left:.5in'><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:windowtext'>Mitch<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:windowtext'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:windowtext'><o:p> </o:p></span></p><p class=MsoNormal style='margin-left:.5in'><b><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:windowtext'>Lahne Mattas-Curry<o:p></o:p></span></b></p><p class=MsoNormal style='margin-left:.5in'><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:windowtext'>U.S. EPA<o:p></o:p></span></p><p class=MsoNormal style='margin-left:.5in'><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:windowtext'>Office of Research and Development<o:p></o:p></span></p><p class=MsoNormal style='margin-left:.5in'><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:windowtext'>Communications<o:p></o:p></span></p><p class=MsoNormal style='margin-left:.5in'><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:windowtext'>Office: 202.564.3165<o:p></o:p></span></p><p class=MsoNormal style='margin-left:.5in'><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:windowtext'>cell: 202.573.0346”<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:windowtext'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:windowtext'>So I would argue that our water is safe except for Cytotoxic chemotherapy drugs and we need a national policy on controlling cytotoxic drugs and the urine and feces that contain the drugs similar to the way we control uranium and plutonium as they have similar Genotoxic properties.<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:windowtext'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:windowtext'>Once again check out <a href="http://www.cytotoxicsafety.org">www.cytotoxicsafety.org</a> <o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:windowtext'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:windowtext'>Thank you all <o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:windowtext'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:windowtext'>Jim Mullowney <o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:windowtext'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><div><div style='border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0in 0in 0in'><p class=MsoNormal><b><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif";color:windowtext'>From:</span></b><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif";color:windowtext'> pharmwaste-bounces@lists.dep.state.fl.us [mailto:pharmwaste-bounces@lists.dep.state.fl.us] <b>On Behalf Of </b>DeBiasi, Deborah (DEQ)<br><b>Sent:</b> Monday, September 29, 2014 11:26 AM<br><b>To:</b> pharmwaste@lists.dep.state.fl.us<br><b>Subject:</b> [Pharmwaste] Pharmaceuticals in municipal wastewater<o:p></o:p></span></p></div></div><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal>Here is the presentation that EPA sponsored last week. <o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=Default><b><span style='font-size:16.0pt;font-family:"Times New Roman","serif"'>Pharmaceuticals in municipal wastewater </span></b><span style='font-size:16.0pt;font-family:"Times New Roman","serif"'><o:p></o:p></span></p><p class=Default><b><span style='font-family:"Times New Roman","serif"'>Office of Research and Development </span></b><span style='font-family:"Times New Roman","serif"'><o:p></o:p></span></p><p class=Default><span style='font-family:"Times New Roman","serif"'>National Exposure Research Laboratory </span><span style='font-size:9.0pt;font-family:"Times New Roman","serif"'><o:p></o:p></span></p><p class=Default><i><span style='font-size:10.0pt;font-family:"Times New Roman","serif"'>Although this work was reviewed by EPA and approved for publication, it may not necessarily reflect official Agency policy. </span></i><span style='font-size:10.0pt;font-family:"Times New Roman","serif"'><o:p></o:p></span></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal style='text-autospace:none'><span style='color:black'>by Mitch Kostich, Angela Batt, Susan Glassmeyer and Jim Lazorchak </span><o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal>September 24, 2014<o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><a href="http://www2.epa.gov/sites/production/files/2014-09/documents/sswr_pharmaceuticals_in_wastewater_webinar_sept_2014.pdf">http://www2.epa.gov/sites/production/files/2014-09/documents/sswr_pharmaceuticals_in_wastewater_webinar_sept_2014.pdf</a><o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><span style='font-size:10.0pt;color:navy'>Deborah L. DeBiasi</span><span style='font-size:11.0pt;color:navy'><br></span><b><span style='font-size:10.0pt;color:navy'>Email: <a href="mailto:Deborah.DeBiasi@deq.virginia.gov">Deborah.DeBiasi@deq.virginia.gov</a></span></b><b><i><span style='font-size:10.0pt;color:red'><br></span></i></b><span style='font-size:10.0pt;color:navy'>WEB site address: <a href="http://www.deq.virginia.gov/">www.deq.virginia.gov</a></span><span style='font-size:11.0pt;color:navy'><br></span><span style='font-size:10.0pt;color:navy'>Virginia Department of Environmental Quality</span><span style='font-size:11.0pt;color:navy'><br></span><span style='font-size:10.0pt;color:navy'>Office of Water Permits </span><span style='font-size:11.0pt;color:navy'><br></span><span style='font-size:10.0pt;color:navy'>Industrial Pretreatment/Whole Effluent Toxicity (WET) Program</span><span style='font-size:11.0pt;color:navy'><br></span><span style='font-size:10.0pt;color:navy'>PPCPs, EDCs, and Microconstituents<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;color:navy'><a href="http://www.deq.virginia.gov/Programs/Water/PermittingCompliance/PollutionDischargeElimination/Microconstituents.aspx">http://www.deq.virginia.gov/Programs/Water/PermittingCompliance/PollutionDischargeElimination/Microconstituents.aspx</a></span><span style='font-size:10.0pt;color:navy'><o:p></o:p></span></p><p class=MsoNormal><span style='font-size:10.0pt;color:navy'>Mail: P.O. Box 1105, Richmond, VA 23218</span><span style='font-size:11.0pt;color:navy'><br></span><span style='font-size:10.0pt;color:navy'>Location: 629 E. Main Street, Richmond, VA 23219</span><span style='font-size:11.0pt;color:navy'><br></span><span style='font-size:10.0pt;color:navy'>PH: 804-698-4028 FAX: 804-698-4032<o:p></o:p></span></p><p class=MsoNormal><o:p> </o:p></p></div></body></html>