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<p class="MsoNormal"><font size="3" color="#000099" face="Times New Roman"><span style="font-size:12.0pt"><a href="http://www.environmentalhealthnews.org/ehs/news/2014/oct/plastics-chemical-and-boys-genitals">http://www.environmentalhealthnews.org/ehs/news/2014/oct/plastics-chemical-and-boys-genitals</a></span><o:p></o:p></font></p>
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<b><font size="6" color="black" face="Times New Roman"><span style="font-size:24.0pt;color:windowtext;font-weight:bold">Plastics chemical linked to changes in baby boys' genitals
<o:p></o:p></span></font></b></p>
<p class="MsoNormal"><font size="3" color="black" face="Times New Roman"><span style="font-size:12.0pt;color:windowtext"><a href="javascript:void(0)" title="ShareThis via email, AIM, social bookmarking and networking sites, etc."><font color="blue"><span style="color:blue">ShareThis</span></font></a><o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="3" color="black" face="Times New Roman"><span style="font-size:12.0pt;color:windowtext">By
<a href="http://www.environmentalhealthnews.org/archives.jsp?sm=&tn=0reporter&tv=Lindsey+Konkel&ss=1">
<font size="1" color="blue"><span style="font-size:7.0pt;color:blue">Lindsey Konkel</span></font></a><o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="3" color="black" face="Times New Roman"><span style="font-size:12.0pt;color:windowtext">Environmental Health News<o:p></o:p></span></font></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><font size="3" color="black" face="Times New Roman"><span style="font-size:12.0pt;color:windowtext">Oct. 29, 2014<o:p></o:p></span></font></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><font size="3" color="black" face="Times New Roman"><span style="font-size:12.0pt;color:windowtext">Boys exposed in the womb to high levels of a chemical found in vinyl products
are born with slightly altered genital development, according to <a href="http://ehp.niehs.nih.gov/1408163/">
<font color="blue"><span style="color:blue">research</span></font></a> published today.<o:p></o:p></span></font></p>
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<font size="3" color="black" face="Times New Roman"><span style="font-size:12.0pt;color:windowtext"><img border="0" width="130" height="84" id="Picture_x0020_1" src="cid:image001.gif@01CFF9B6.6CB99720" alt="http://www.environmentalhealthnews.org/ehs/images/2014/badges/new_sci-badge_fp"></span></font><font color="black"><span style="color:windowtext"><o:p></o:p></span></font></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><font size="3" color="black" face="Times New Roman"><span style="font-size:12.0pt;color:windowtext">The study of nearly 200 Swedish babies is the first to link the chemical di-isononyl
phthalate (DiNP) to changes in the development of the human male reproductive tract.<o:p></o:p></span></font></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><font size="3" color="black" face="Times New Roman"><span style="font-size:12.0pt;color:windowtext"><a href="http://www.ncbi.nlm.nih.gov/pubmed/24349678"><font color="blue"><span style="color:blue">Previous</span></font></a>
<a href="http://www.ncbi.nlm.nih.gov/pubmed/21696396"><font color="blue"><span style="color:blue">studies</span></font></a> of baby boys in three countries found that a similar plastics chemical, DEHP, was associated with the same type of changes in their genitalia.<o:p></o:p></span></font></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><font size="3" color="black" face="Times New Roman"><span style="font-size:12.0pt;color:windowtext">Less is known about the reproductive risks of DiNP, a chemical which scientists
say may be replacing DEHP in many products such as vinyl toys, flooring and packaging. In mice, high levels block testosterone and alter testicular development.<o:p></o:p></span></font></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><font size="3" color="black" face="Times New Roman"><span style="font-size:12.0pt;color:windowtext">“Our data suggest that this substitute phthalate may not be safer than the chemical
it is replacing,” wrote the researchers, led by Carl-Gustaf Bornehag at Sweden’s Karlstad University, in the journal Environmental Health Perspectives.<o:p></o:p></span></font></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><font size="3" color="black" face="Times New Roman"><span style="font-size:12.0pt;color:windowtext">Levels of DiNP in U.S. adults and children have more than doubled in the past
decade.<o:p></o:p></span></font></p>
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<font size="3" color="black" face="Times New Roman"><span style="font-size:12.0pt;color:windowtext"><img border="0" width="400" height="225" id="Picture_x0020_2" src="cid:image002.jpg@01CFF9B6.6CB99720" alt="http://www.environmentalhealthnews.org/ehs/images/2014/ehn/oct/phthalates/newborn.jpg"></span></font><font color="black"><span style="color:windowtext"><o:p></o:p></span></font></p>
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<font size="1" color="#999999" face="Times New Roman"><span style="font-size:9.0pt;color:#999999"><a href="https://www.flickr.com/photos/rtdphotography/2979836365"><font color="blue"><span style="color:blue">Ray Dumas/flickr</span></font></a><o:p></o:p></span></font></p>
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<font size="2" color="#555555" face="Times New Roman"><span style="font-size:10.0pt;color:#555555">Phthalate chemicals found in vinyl products have been linked to altered genital development in baby boys.<o:p></o:p></span></font></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><font size="3" color="black" face="Times New Roman"><span style="font-size:12.0pt;color:windowtext">“This study raises concern about DiNP, which is being used in increased amounts
in products that contain vinyl plastics, and the impact on the developing fetus,” said Dr. Russ Hauser, a professor of environmental and occupational epidemiology at Harvard School of Public Health who is not involved in the new study.<o:p></o:p></span></font></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><font size="3" color="black" face="Times New Roman"><span style="font-size:12.0pt;color:windowtext">The researchers measured metabolites of five phthalates in the urine of pregnant
women during the first trimester. Development of male reproductive organs begins during that period, said senior study author Shanna Swan, a professor of reproductive science at Mount Sinai Hospital in New York.<o:p></o:p></span></font></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><font size="3" color="black" face="Times New Roman"><span style="font-size:12.0pt;color:windowtext">The researchers then measured the anogenital distance – the length between the
anus and the genitals – when the boys were on average 21 months old. Boys who had been exposed to the highest levels of DiNP in the womb averaged a distance that was slightly shorter – about seven-hundredths of an inch – than the boys with the lowest exposures.<o:p></o:p></span></font></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><font size="3" color="black" face="Times New Roman"><span style="font-size:12.0pt;color:windowtext">“These were really subtle changes,” Swan said.<o:p></o:p></span></font></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><font size="3" color="black" face="Times New Roman"><span style="font-size:12.0pt;color:windowtext">Considered a sign of incomplete masculinization, shortened anogenital distance
in men has been associated with abnormal testicular development and reduced semen quality and fertility. In men, this measurement is typically 50 to 100 percent longer than in women.<o:p></o:p></span></font></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><font size="3" color="black" face="Times New Roman"><span style="font-size:12.0pt;color:windowtext">But it’s unknown whether a slightly shorter distance in infants corresponds with
any fertility problems later in life.<o:p></o:p></span></font></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><font size="3" color="black" face="Times New Roman"><span style="font-size:12.0pt;color:windowtext">“More research is needed to understand the extent to which shorter anogenital
distance at birth is associated with impaired reproductive function later in life in humans,” said Emily Barrett, a reproductive health scientist at the University of Rochester Medical Center in New York.<o:p></o:p></span></font></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><font size="3" color="black" face="Times New Roman"><span style="font-size:12.0pt;color:windowtext">For other phthalates, the study found shorter anogenital distance with higher
concentrations, but the findings were not statistically significant, meaning they may have been due to chance. The Swedish women in the new study had phthalate levels similar to U.S. women in Swan's previous studies. Those studies, published in
<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1280349/"><font color="blue"><span style="color:blue">2005</span></font></a> and
<a href="http://shswan.com/wp-content/uploads/2010/03/Swan-2008-Environmental-phthalate-exposure-in-relation-to-reproductive-outcomes-and-other-health-endpoints-in-humans.pdf">
<font color="blue"><span style="color:blue">2008</span></font></a>, linked several phthalates to shorter anogenital distance.<o:p></o:p></span></font></p>
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<font size="3" color="black" face="Times New Roman"><span style="font-size:12.0pt;color:windowtext"><img border="0" width="264" height="300" id="Picture_x0020_3" src="cid:image005.jpg@01CFF9D2.18DE1650" alt="http://www.environmentalhealthnews.org/ehs/images/2014/ehn/oct/phthalates/pregnant.jpg/"></span></font><font color="black"><span style="color:windowtext"><o:p></o:p></span></font></p>
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<font size="1" color="#999999" face="Times New Roman"><span style="font-size:9.0pt;color:#999999"><a href="https://www.flickr.com/photos/tvanardenne/5390922928"><font color="blue"><span style="color:blue">Thomas van Ardenne</span></font></a><o:p></o:p></span></font></p>
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<font size="2" color="#555555" face="Times New Roman"><span style="font-size:10.0pt;color:#555555">Pregnant women may be exposed to phthalates through food or through skin contact with home products.<o:p></o:p></span></font></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><font size="3" color="black" face="Times New Roman"><span style="font-size:12.0pt;color:windowtext">A spokesperson for the American Chemistry Council, a group representing chemical
manufacturers, said the study "reports small changes that are associated with exposure to DiNP" but does not prove that the chemical caused the changes.
<o:p></o:p></span></font></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><font size="3" color="black" face="Times New Roman"><span style="font-size:12.0pt;color:windowtext">The spokesperson said the new findings "seem to contradict" the authors' earlier
findings as well as two other studies that found no association between DiNP and men's anogenital distance. In addition, the study is based on a single urine sample from the mothers. As a result, the "plausibility is low," the industry group said. "To demonstrate
causal associations in the field of epidemiology, there are criteria that should be evaluated and considered...We found that this study scores low for many important considerations."<o:p></o:p></span></font></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><font size="3" color="black" face="Times New Roman"><span style="font-size:12.0pt;color:windowtext">The industry group did not answer questions about what types of products DiNP
is used in. The scientists said exposures to the chemical can come from food or through skin contact with home furnishings or child-care articles.<o:p></o:p></span></font></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><font size="3" color="black" face="Times New Roman"><span style="font-size:12.0pt;color:windowtext">In 2008, the United States temporarily banned use of DiNP and two other phthalate
plasticizers in toys and other children's products. “This ban does nothing to protect the developing fetus,” Swan said.<o:p></o:p></span></font></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><font size="3" color="black" face="Times New Roman"><span style="font-size:12.0pt;color:windowtext">The Consumer Product Safety Commission
<a href="http://www.cpsc.gov/PageFiles/169876/CHAP-REPORT-FINAL.pdf"><font color="blue"><span style="color:blue">recommended</span></font></a> in July to make the ban permanent and urged that “U.S. agencies responsible for dealing with DiNP exposures from food
and other products conduct the necessary risk assessments.”<o:p></o:p></span></font></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><font size="3" color="black" face="Times New Roman"><span style="font-size:12.0pt;color:windowtext">While it’s nearly impossible to eliminate exposure to phthalates, Swan suggested
that pregnant women may be able to reduce their exposures by incorporating unprocessed, unpackaged foods into the diet and by avoiding heating or storing foods in plastic containers.<o:p></o:p></span></font></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><font size="3" color="black" face="Times New Roman"><span style="font-size:12.0pt;color:windowtext"><br>
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in Chief Marla Cone at <a href="mailto:mcone@ehn.org"><font color="blue"><span style="color:blue">mcone@ehn.org</span></font></a>.</span></font></i><font color="black"><span style="color:windowtext"><o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="3" color="#000099" face="Times New Roman"><o:p> </o:p></font></p>
<p class="MsoNormal"><font size="3" color="#000099" face="Times New Roman"><o:p> </o:p></font></p>
<p class="MsoNormal"><font size="2" color="navy" face="Times New Roman"><span style="font-size:10.0pt;color:navy">Deborah L. DeBiasi</span></font><font size="2" color="navy"><span style="font-size:11.0pt;color:navy"><br>
</span></font><b><font size="2" color="navy"><span style="font-size:10.0pt;color:navy;font-weight:bold">Email: Deborah.DeBiasi@deq.virginia.gov</span></font></b><b><i><font size="2" color="red"><span style="font-size:10.0pt;color:red;font-weight:bold;font-style:italic"><br>
</span></font></i></b><font size="2" color="navy"><span style="font-size:10.0pt;color:navy">WEB site address:
<a href="http://www.deq.virginia.gov/">www.deq.virginia.gov</a></span></font><font size="2" color="navy"><span style="font-size:11.0pt;color:navy"><br>
</span></font><font size="2" color="navy"><span style="font-size:10.0pt;color:navy">Virginia Department of Environmental Quality</span></font><font size="2" color="navy"><span style="font-size:11.0pt;color:navy"><br>
</span></font><font size="2" color="navy"><span style="font-size:10.0pt;color:navy">Office of Water Permits
</span></font><font size="2" color="navy"><span style="font-size:11.0pt;color:navy"><br>
</span></font><font size="2" color="navy"><span style="font-size:10.0pt;color:navy">Industrial Pretreatment/Whole Effluent Toxicity (WET) Program</span></font><font size="2" color="navy"><span style="font-size:11.0pt;color:navy"><br>
</span></font><font size="2" color="navy"><span style="font-size:10.0pt;color:navy">PPCPs, EDCs, and Microconstituents<o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" color="navy" face="Times New Roman"><span style="font-size:11.0pt;color:navy"><a href="http://www.deq.virginia.gov/Programs/Water/PermittingCompliance/PollutionDischargeElimination/Microconstituents.aspx">http://www.deq.virginia.gov/Programs/Water/PermittingCompliance/PollutionDischargeElimination/Microconstituents.aspx</a></span></font><font size="2" color="navy"><span style="font-size:10.0pt;color:navy"><o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" color="navy" face="Times New Roman"><span style="font-size:10.0pt;color:navy">Mail: P.O. Box 1105, Richmond, VA 23218</span></font><font size="2" color="navy"><span style="font-size:11.0pt;color:navy"><br>
</span></font><font size="2" color="navy"><span style="font-size:10.0pt;color:navy">Location: 629 E. Main Street, Richmond, VA 23219</span></font><font size="2" color="navy"><span style="font-size:11.0pt;color:navy"><br>
</span></font><font size="2" color="navy"><span style="font-size:10.0pt;color:navy">PH: 804-698-4028 FAX: 804-698-4032<o:p></o:p></span></font></p>
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