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<p>New info from Jim Mullowney below. Contact him for more information: <span tabindex="-1" contentEditable="false">
<span onclick="_e(this,this.getAttribute("_e_onclick"), event)" tabindex="-1" ondblclick="_e(this,this.getAttribute("_e_ondblclick"), event)" id="spnR" title="jmullowney@pharma-cycle.com" class="rwRR" contentEditable="true" onkeydown="_e(this,this.getAttribute("_e_onkeydown"), event)" oncontextmenu="_e(this,this.getAttribute("_e_oncontextmenu"), event)" ondrop="return(false);" _e_onclick="onClkRcp(event);" _dn="Jim Mullowney [jmullowney@pharma-cycle.com]" _em="jmullowney@pharma-cycle.com" _sa="jmullowney@pharma-cycle.com" _ao="3" _rt="SMTP" _rf="0" _e_oncontextmenu="onContextMenuSpnRw(event);" _e_onkeydown="onKDRcp(event);" _e_ondblclick="onDblClkRcp(event);"> <a href="mailto:jmullowney@pharma-cycle.com">jmullowney@pharma-cycle.com</a></span></span></p>
<p> </p>
<p>Unofficial draft of the updated USP [set standards, publish International Pharmacopoeia] "General
<font face="Tahoma">Chapter <800> on Hazardous Drugs, handling in healthcare settings" states that materials with trace amounts of Hazardous Drugs must be discarded as a Hazardous Waste. This includes items contaminated in the medical care facility and patient-care
environment, which can include the home. </font></p>
<p> </p>
<p align="left"></p>
<p>Problem Chemotherapy Drugs That Are Excreted at High Concentrations & Can Damage Others at Ultra-low Doses1</p>
<p>Generic Name Other Names Excretion Administered Dose</p>
<p> % Danger Period Dose/Weight Amount</p>
<p>Actinomycin D Dactinomycin, Cosmenogen 30% 7 Days ˜ 50 ug/Kg ˜ 4 mg<br>
Bleomycin Blenoxane 60-70% 1 Day ˜ 50 units (mg)/Kg ˜ 4000 mg<br>
Carboplatin Paraplatin 65-75% 1 Day ˜ 12 mg/Kg ˜ 960 mg<br>
Cisplatin Platin 13-17% 1 Day ˜ 3.3 mg/Kg ˜ 264 mg<br>
Cyclophosphamide Endoxan, Cytoxan, Neosar, Procytox, Revimmune </p>
<p> 5-25% 1 Day ˜ 50 mg/Kg ˜ 4000 mg<br>
Dacarbazine DTIC, DTIC-Dome 40% 1 Day ˜ 4.5 mg/Kg ˜ 360 mg<br>
Daunorubicin HCl Cerubidine 65% 3 Days ˜ 1.5 mg/Kg ˜120 mg<br>
Doxorubicin Adriamycin, Rubex, Doxil, Caelyx, Myocet </p>
<p> 45-55% 5 Days ˜ 2.5 mg/Kg ˜ 200 mg<br>
Epirubicin Ellence, Pharmorubicin 55% 4 Days ˜ 40 mg/Kg ˜ 3200 mg<br>
Etoposide Eposin, Etopophos, Vepesid, VP-16 45% 5 Days ˜ 3.3 mg/Kg ˜ 264 mg<br>
Floxuridine Fdur 20% 1 Day ˜ 0.6 mg/Kg ˜ 48 mg<br>
Fludarabine Fludara 40-60% 1 Day ˜ 0.83 mg/Kg ˜ 66.4 mg<br>
Fluorouracil 5-FU, Adrucil, Carac, Efudix, Efudex, Fluoroplex</p>
<p> 7-20% 1 Day ˜ 12 mg/Kg ˜ 960 mg<br>
Idarubicin Zavedos, Idamycin 20% 8 Days ˜ 0.4 mg/Kg ˜ 32 mg<br>
Ifosfamide Mitoxana, Ifex 12-18% 1 Day ˜ 40 mg/Kg ˜ 3200 mg<br>
Irinotecan Camptosar, Campto 25-50% 2 Days ˜ 11.7 mg/Kg ˜ 936 mg<br>
Mitomycin Mitosol 10% 1 Day ˜ 0.67 mg/Kg ˜ 53.6 mg<br>
Mitoxantrone 24% 5 Days ˜ 0.47 mg/Kg ˜ 37.6 mg<br>
Oxaliplatin Eloxatin 35% 1 Day ˜ 2.8 mg/Kg ˜ 224 mg<br>
Methotrexate Trexall, MTX, Amethopterin 80-90% 1 Day ˜ 15 mg/Kg ˜ 1200 mg<br>
Temozolomide Temodar 18% 7 Days ˜ 50 mg/Kg ˜ 4000 mg<br>
Topotecan Hycamtin 70 -75% 9 Days ˜ 0.05 mg/Kg ˜ 4 mg<br>
Restricted use<br>
Arsenic trioxide Trisenox 15% 1 Day ˜ 15 mg/Kg ˜ 1200 mg<br>
Clofarabine 49-60% 1 Day ˜ 1.7 mg/Kg ˜ 138 mg<br>
Melphalan Alkeran 10-15% 1 Day 6 mg 6 mg<br>
Teniposide Vumon 4-12% 5 Days ˜ 8.3 mg/Kg ˜ 666 mg<br>
Valrubicin Valstar 99% 1 Day 800 mg 800 mg<br>
1. Information summarized from the Drug Package Inserts - information required by the FDA from pharmaceutical companies before each drug is approved for use in humans.</p>
<p>2. Estimated percent of drug dose that exits patient's body as parental drug or active metabolite as well as excretion period.</p>
<p>3. Doses will vary depending on disease and doctors' recommendations. See individual Drug Inserts for more details.<br>
4. Where needed, converted from mg/m2 to mg/Kg</p>
<p> </p>
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<div style="FONT-SIZE: 13px; FONT-FAMILY: Tahoma"><font size="+0"><span lang="en-US">
<div><font size="2"><span style="FONT-SIZE: 10pt; FONT-FAMILY: "Tahoma","sans-serif"; COLOR: black">Ed Gottlieb
<br>
Industrial Pretreatment Coordinator<br>
Ithaca Area Wastewater Treatment Facility<br>
525 3<sup>rd</sup> Street<br>
Ithaca, NY 14850<br>
</span><span style="FONT-SIZE: 10pt; FONT-FAMILY: "Tahoma","sans-serif"; COLOR: blue"><a href="tel:(607)%20273-8381" target="_blank"><font color="#0000ff">(607) 273-8381</font></a><br>
</span><span style="FONT-SIZE: 10pt; FONT-FAMILY: "Tahoma","sans-serif"; COLOR: black">fax:
<a href="tel:(607)%20273-8433" target="_blank"><span style="COLOR: rgb(0,102,204)">(607) 273-8433</span></a></span></font></div>
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