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--></style></head><body lang="EN-US" link="#0563C1" vlink="#954F72"><div class="WordSection1"><p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#0000cc"><a href="https://www.epa.gov/sites/production/files/2018-09/documents/fish-news-aug2018.pdf?utm_medium=email&utm_source=govdelivery">https://www.epa.gov/sites/production/files/2018-09/documents/fish-news-aug2018.pdf?utm_medium=email&utm_source=govdelivery</a></span></p><p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#0000cc"> </span></p><p class="Default"><span style="font-size:17.0pt">Selected Pharmaceuticals Not Likely to Persist in Wild Fish: Results of Uptake and Elimination Testing</span></p><p class="Default"><span style="font-size:17.0pt"> </span></p><p class="Default"><span style="font-size:10.0pt;font-family:"Georgia",serif">The U.S. Geological Survey (USGS) reported on May 30, 2018 that a laboratory study shows that both uptake and elimination of selected pharmaceuticals within bluegill tissues is rapid, indicating that persistence in bluegills in the environment is likely to be low except in those fish that reside downstream from a consistent, substantial, contaminant source. </span></p><p class="Default"><span style="font-size:10.0pt;font-family:"Georgia",serif"> </span></p><p class="Default"><span style="font-size:10.0pt;font-family:"Georgia",serif">Pharmaceutical use by humans, subsequent transport to wastewater treatment systems, and release to surface waters have been extensively studied and well documented globally. Chronic and subtle effects of pharmaceutical exposure through water have been reported for non-target fish including those effects related to reproduction, behavior, and growth. Although the effects of contaminants are related to the quantity of a contaminant that reaches an internal organ or tissue, little is known about the details of uptake and elimination of pharmaceuticals by exposed fish. </span></p><p class="Default"><span style="font-size:10.0pt;font-family:"Georgia",serif"> </span></p><p class="Default"><span style="font-size:10.0pt;font-family:"Georgia",serif">To this end, USGS, Chinese Academy of Science, and St. Cloud State University scientists investigated the uptake and elimination of five pharmaceuticals in bluegill sunfish to aid in understanding the exposure risks, if any, to aquatic organisms or to humans through fish consumption. </span></p></div><span style="font-size:12.0pt;font-family:"Franklin Gothic Demi",sans-serif"><br clear="all" style="page-break-before:auto"></span><div class="WordSection2"><p class="Default"><span style="font-size:10.0pt;font-family:"Georgia",serif;color:windowtext"> </span></p><p class="Default"><span style="font-size:10.0pt;font-family:"Georgia",serif;color:windowtext">A laboratory flow-through system was used to expose fish to pharmaceutical concentrations that mimicked those found in close proximity to continuously discharging wastewater outflows. Five commonly prescribed pharmaceuticals with different physio-chemical properties were used for the exposures: </span></p><p class="Default"><span style="font-size:10.0pt;font-family:"Georgia",serif;color:windowtext"> </span></p><p class="Default" style="margin-bottom:10.85pt"><span style="font-size:10.0pt;font-family:"Georgia",serif;color:windowtext"> Diclofenac (nonsteroidal anti-inflammatory drug) </span></p><p class="Default" style="margin-bottom:10.85pt"><span style="font-size:10.0pt;font-family:"Georgia",serif;color:windowtext"> Methocarbamol (a muscle relaxant) </span></p><p class="Default" style="margin-bottom:10.85pt"><span style="font-size:10.0pt;font-family:"Georgia",serif;color:windowtext"> Rosuvastatin (a drug used to lower cholesterol levels) </span></p><p class="Default" style="margin-bottom:10.85pt"><span style="font-size:10.0pt;font-family:"Georgia",serif;color:windowtext"> Sulfamethoxazole (an antibiotic) </span></p><p class="Default"><span style="font-size:10.0pt;font-family:"Georgia",serif;color:windowtext"> Temazepam (a sleep aid) </span></p><p class="Default"><span style="font-size:10.0pt;font-family:"Georgia",serif;color:windowtext"> </span></p><p class="Default"><span style="font-size:10.0pt;font-family:"Georgia",serif;color:windowtext">Temazepam and methocarbamol were consistently detected in bluegill samples, so their uptake and elimination was studied in more detail. Over 30-day exposures, temazepam and methocarbamol demonstrated relatively rapid uptake and rapid elimination, indicating that internal tissue concentrations were driven by external environmental concentrations. This information indicates that overall persistence of the selected pharmaceuticals within bluegill tissues in the environment is likely to be low unless they reside downstream from a consistent, substantial, external contaminant source. </span></p><p class="Default"><span style="font-size:10.0pt;font-family:"Georgia",serif;color:windowtext"> </span></p></div><span style="font-size:12.0pt;font-family:"Franklin Gothic Demi",sans-serif"><br clear="all" style="page-break-before:always"></span><div class="WordSection3"><p class="Default" style="page-break-before:always"><span style="font-size:10.0pt;font-family:"Georgia",serif;color:windowtext">The pattern of rapid uptake and elimination observed for bluegill in this study is not dissimilar to that which is observed for human subjects, indicating that the modeling of pharmaceutical uptake done as part of the drug approval process could be used to inform future study design and prioritize research needs for the Nation. </span></p><p class="Default" style="page-break-before:always"><span style="font-size:10.0pt;font-family:"Georgia",serif;color:windowtext"> </span></p><p class="Default"><span style="font-size:10.0pt;font-family:"Georgia",serif;color:windowtext">While this study provides a greater understanding of pharmaceutical persistence in fish tissue, the significance in terms of fish health has yet to be determined. This study was the first step in a longer-term challenge for the USGS Environmental Health programs as they continue to provide the science to understand the sources, transport, fate, exposure, and adverse health effects, if any of contaminants in the environment. </span></p><p class="Default"><span style="font-size:10.0pt;font-family:"Georgia",serif;color:windowtext"> </span></p><p class="Default"><span style="font-size:10.0pt;font-family:"Georgia",serif;color:windowtext">The USGS Toxic Substances Hydrology Program funded this study. </span></p><p class="Default"><span style="font-size:14.0pt;font-family:"Franklin Gothic Demi Cond",sans-serif;color:windowtext">Reference </span></p><p class="Default"><span style="font-size:10.0pt;font-family:"Georgia",serif;color:windowtext">Zhao, J.-L., E.T. Furlong, H.L. Schoenfuss, D.W. Kolpin, K.L. Bird, D.J. Feifarek, E.A. Schwab, G.G. Ying. 2017. Uptake and disposition of select pharmaceuticals by bluegill exposed at constant concentrations in a flow-through aquatic exposure system. <i>Environmental Science and Technology </i>51(8):4434-4444. </span></p><p class="Default"><span style="font-size:10.0pt;font-family:"Georgia",serif;color:windowtext">For more information, contact Edward T. Furlong at 303-236-3941 or <a href="mailto:efurlong@usgs.gov">efurlong@usgs.gov</a>, or Dana W. Kolpin at 319-358-3614 or <a href="mailto:dwkolpin@usgs.gov">dwkolpin@usgs.gov</a>. </span></p><p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Georgia",serif">Source: <a href="https://www2.usgs.gov/envirohealth/headlines/2018-05-30-pharmaceuticals_in_wild_fish.html">https://www2.usgs.gov/envirohealth/headlines/2018-05-30-pharmaceuticals_in_wild_fish.html</a></span></p><p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Georgia",serif"> </span></p><p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Georgia",serif"> </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:17.0pt;font-family:"Franklin Gothic Demi",sans-serif;color:black">Journal Articles </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:10.0pt;font-family:"Georgia",serif;color:black">The list below provides a selection of research articles focusing on pharmaceuticals. </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.0pt;font-family:"Times New Roman",serif;color:black">► </span><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black">Pharmaceuticals in water, fish and osprey nestlings in Delaware River and Bay </span><span style="font-size:9.0pt;font-family:"Franklin Gothic Demi",sans-serif;color:black"></span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:9.0pt;font-family:"Franklin Gothic Demi",sans-serif;color:black"> </span></p><p class="MsoNormal"><span style="font-size:8.5pt;font-family:"Franklin Gothic Book",sans-serif;color:black">Bean, T.G., B.A. Rattner, R.S. Lazarus, et al. 2018. Pharmaceuticals in water, fish and osprey nestlings in Delaware River and Bay. <i>Environmental Pollution </i>232:533-545. </span><span style="font-size:10.0pt;font-family:"Georgia",serif"></span></p><p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Georgia",serif"> </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:12.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif"> </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black">Development of an opioid self-administration assay to study drug seeking in zebrafish </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black"> </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.5pt;font-family:"Franklin Gothic Book",sans-serif;color:black">Bosse, G.D. and R.T. Peterson. 2017. Development of an opioid self-administration assay to study drug seeking in zebrafish. <i>Behavioural Brain Research </i>335:158-166. </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.0pt;font-family:"Times New Roman",serif;color:black">► </span><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black">Effect of human pharmaceuticals common to aquatic environments on hepatic CYP1A and CYP3A-like activities in rainbow trout (Oncorhynchus mykiss): An in vitro study </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black"> </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.5pt;font-family:"Franklin Gothic Book",sans-serif;color:black">Burkina, V., S. Sakalli, N. Pilipenko, V. Zlabek, and G. Zamaratskaia. 2018. Effect of human pharmaceuticals common to aquatic environments on hepatic CYP1A and CYP3A like activities in rainbow trout (<i>Oncorhynchus mykiss</i>): An <i>in vitro </i>study. <i>Chemosphere </i>205:380-386. </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.0pt;font-family:"Times New Roman",serif;color:black">► </span><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black">Occurrence of antibiotics in mussels and clams from various FAO areas </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black"> </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.5pt;font-family:"Franklin Gothic Book",sans-serif;color:black">Chiesa, L.M., M. Nobile, R. Malandra, S. Panseri, and F. Arioli. 2018. Occurrence of antibiotics in mussels and clams from various FAO areas. <i>Food Chemistry </i>240:16-23. </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.0pt;font-family:"Times New Roman",serif;color:black">► </span><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black">Concentrating mixtures of neuroactive pharmaceuticals and altered neurotransmitter levels in the brain of fish exposed to a wastewater effluent </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black"> </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.5pt;font-family:"Franklin Gothic Book",sans-serif;color:black">David, A., A. Lange, C.R. Tyler, and E.M. Hill. 2018. Concentrating mixtures of neuroactive pharmaceuticals and altered neurotransmitter levels in the brain of fish exposed to a wastewater effluent. <i>Science of The Total Environment </i>621:782-790. </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.0pt;font-family:"Times New Roman",serif;color:black">► </span><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black">Pharmaceuticals and personal care products (PPCPs) in the freshwater aquatic environment </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black"> </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.5pt;font-family:"Franklin Gothic Book",sans-serif;color:black">Ebele, A.J., M. A-E. Abdallah, and S. Harrad. 2017. Pharmaceuticals and personal care products (PPCPs) in the freshwater aquatic environment. <i>Emerging Contaminants </i>3(1):1-16. </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.0pt;font-family:"Times New Roman",serif;color:black">► </span><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black">Bioaccumulation of psychoactive pharmaceuticals in fish in an effluent dominated stream </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black"> </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.5pt;font-family:"Franklin Gothic Book",sans-serif;color:black">Grabicova, K., R. Grabic, G. Fedorova, et al. 2017. Bioaccumulation of psychoactive pharmaceuticals in fish in an effluent dominated stream. <i>Water Research </i>124:654-662. </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.0pt;font-family:"Times New Roman",serif;color:black">► </span><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black">How cyclophosphamide at environmentally relevant concentration influences Daphnia magna life history and its proteome </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black"> </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.5pt;font-family:"Franklin Gothic Book",sans-serif;color:black">Grzesiuk, M., D. Mielecki, T. Pilżys, D. Garbicz, M. Marcinkowski, and E. Grzesiuk. 2018. How cyclophosphamide at environmentally relevant concentration influences <i>Daphnia magna </i>life history and its proteome. <i>PLoS ONE </i>13(4): e0195366. </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.0pt;font-family:"Times New Roman",serif;color:black">► </span><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black">Social hierarchy modulates responses of fish exposed to contaminants of emerging concern </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black"> </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.5pt;font-family:"Franklin Gothic Book",sans-serif;color:black">Ivanova, J., S. Zhang, R-L. Wang, and H.L. Schoenfuss. 2017. Social hierarchy modulates responses of fish exposed to contaminants of emerging concern. <i>PLoS ONE </i>12(10): e0186807. </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.0pt;font-family:"Times New Roman",serif;color:black">► </span><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black">Measurement of aquaculture chemotherapeutants in flocculent matter collected at a hard-bottom dominated finfish site on the south coast of Newfoundland (Canada) after 2 years of fallow </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black"> </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.5pt;font-family:"Franklin Gothic Book",sans-serif;color:black">Hamoutene, D., F. Salvo, S.N. Egli, A. Modir-Rousta, et al. 2018. Measurement of aquaculture chemotherapeutants in flocculent matter collected at a hard-bottom dominated finfish site on the south coast of Newfoundland (Canada) after 2 years of fallow. <i>Frontiers in Marine Science </i>5:228. </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.0pt;font-family:"Times New Roman",serif;color:black">► </span><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black">Presence of pharmaceuticals in fish collected from urban rivers in the U.S. EPA 2008-2009 National Rivers and Streams Assessment </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black"> </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.5pt;font-family:"Franklin Gothic Book",sans-serif;color:black">Huerta, B., S. Rodriguez-Mozaz, J. Lazorchak, D. Barcelo, A. Batt, J. Wathen, and L. Stahl. 2018. Presence of pharmaceuticals in fish collected from urban rivers in the U.S. EPA 2008-2009 National Rivers and Streams Assessment. <i>Science of The Total Environment </i>634:542-549. </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.0pt;font-family:"Times New Roman",serif;color:black">► </span><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black">Transport of pharmaceuticals and their metabolites between water and sediments as a further potential exposure for aquatic organisms </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black"> </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.5pt;font-family:"Franklin Gothic Book",sans-serif;color:black">Koba, O., K. Grabicova, D. Cerveny, et al. 2018. Transport of pharmaceuticals and their metabolites between water and sediments as a further potential exposure for aquatic organisms. <i>Journal of Hazardous Materials </i>342:401-407. </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.0pt;font-family:"Times New Roman",serif;color:black">► </span><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black">Antibiotic pollution in marine food webs in Laizhou Bay, North China: Trophodynamics and human exposure implication </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black"> </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.5pt;font-family:"Franklin Gothic Book",sans-serif;color:black">Liu, S., H. Zhao, H.J. Lehmler, X. Cai, and J. Chen. 2017. Antibiotic Pollution in Marine Food Webs in Laizhou Bay, North China: Trophodynamics and Human Exposure Implication. <i>Environmental Science & Technology</i>, 51(4):2392-2400. </span><span style="font-size:8.5pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black"></span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.0pt;font-family:"Times New Roman",serif;color:black">► </span><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black">Usage, residue, and human health risk of antibiotics in Chinese aquaculture: A review </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black"> </span></p><p class="MsoNormal"><span style="font-size:8.5pt;font-family:"Franklin Gothic Book",sans-serif;color:black">Liu, X., J.C. Steele, and X.Z. Meng. 2017. Usage, residue, and human health risk of antibiotics in Chinese aquaculture: A review. <i>Environmental Pollution </i>223:161-169. </span><span style="font-size:10.0pt;font-family:"Georgia",serif"></span></p><p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Georgia",serif"> </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:12.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif"> </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black">Environmental concentrations of metformin exposure affect aggressive behavior in the Siamese fighting fish, Betta splendens </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black"> </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.5pt;font-family:"Franklin Gothic Book",sans-serif;color:black">MacLaren, R.D., K. Wisniewski, and C. MacLaren. 2018. Environmental concentrations of metformin exposure affect aggressive behavior in the Siamese fighting fish, <i>Betta splendens</i>. <i>PLoS ONE </i>13(5): e0197259. </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.0pt;font-family:"Times New Roman",serif;color:black">► </span><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black">Exposure to wastewater effluent affects fish behavior and tissue-specific uptake of pharmaceuticals </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black"> </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.5pt;font-family:"Franklin Gothic Book",sans-serif;color:black">McCallum, E.S., E. Krutzelmann, T. Brodin, J. Fick, A. Sundelin, and S. Balshine. 2017. Exposure to wastewater effluent affects fish behavior and tissue-specific uptake of pharmaceuticals. <i>Science of The Total Environment </i>605-606:578-588. </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.0pt;font-family:"Times New Roman",serif;color:black">► </span><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black">A review of the pharmaceutical exposome in aquatic fauna </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black"> </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.5pt;font-family:"Franklin Gothic Book",sans-serif;color:black">Miller, T.H., N.R. Bury, S.F. Owen, J.I. MacRae, and L.P. Barron. 2018. 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Bioaccumulation of pharmaceuticals and personal care product chemicals in fish exposed to wastewater effluent in an urban wetland. <i>Scientific Reports </i>7: 16999. </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.0pt;font-family:"Times New Roman",serif;color:black">► </span><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black">Tools to assess effects of human pharmaceuticals in fish: A case study with gemfibrozil </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black"> </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.5pt;font-family:"Franklin Gothic Book",sans-serif;color:black">Oliveira, M., L. Franco, J.C. Balasch, et al. 2017. Tools to assess effects of human pharmaceuticals in fish: A case study with gemfibrozil. <i>Ecological Indicators</i>, In Press. </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.0pt;font-family:"Times New Roman",serif;color:black">► </span><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black">Novel electrosorption-enhanced solid-phase microextraction device for ultrafast in vivo sampling of ionized pharmaceuticals in fish </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black"> </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.5pt;font-family:"Franklin Gothic Book",sans-serif;color:black">Qiu, J., F. Wang, T. Zhang, et al. 2018. Novel electrosorption-enhanced solid-phase microextraction device for ultrafast in vivo sampling of ionized pharmaceuticals in fish. <i>Environmental Science & Technology </i>52(1):145-151. </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.0pt;font-family:"Times New Roman",serif;color:black">► </span><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black">Multi-residue method for the determination of antibiotics and some of their metabolites in seafood </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black"> </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.5pt;font-family:"Franklin Gothic Book",sans-serif;color:black">Serra-Compte, A.,D. Álvarez-Muñoz, S. Rodríguez-Mozaz, and D. Barceló. 2016. Multi-residue method for the determination of antibiotics and some of their metabolites in seafood. <i>Food and Chemical Toxicology </i>104:3-13. </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.0pt;font-family:"Times New Roman",serif;color:black">► </span><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black">Reduced anxiety is associated with the accumulation of six serotonin reuptake inhibitors in wastewater treatment effluent exposed goldfish Carassius auratus </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black"> </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.5pt;font-family:"Franklin Gothic Book",sans-serif;color:black">Simmons, D.B.D., E.S. McCallum, S. Balshine, et al. 2017. Reduced anxiety is associated with the accumulation of six serotonin reuptake inhibitors in wastewater treatment effluent exposed goldfish <i>Carassius auratus</i>. <i>Scientific Reports </i>7:17001. </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.0pt;font-family:"Times New Roman",serif;color:black">► </span><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black">Uptake and metabolism of human pharmaceuticals by fish: A case study with the opioid analgesic Tramadol </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black"> </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.5pt;font-family:"Franklin Gothic Book",sans-serif;color:black">Tanoue, R., L. Margiotta-Casaluci, B. Huerta, et al. 2017. Uptake and metabolism of human pharmaceuticals by fish: A case study with the opioid analgesic Tramadol. <i>Environmental Science & Technology </i>51(21):12825-12835. </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.0pt;font-family:"Times New Roman",serif;color:black">► </span><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black">Evaluation of triclosan in Minnesota lakes and rivers: Part II – human health risk assessment </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black"> </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.5pt;font-family:"Franklin Gothic Book",sans-serif;color:black">Yost, L.J., T.R. Barber, P.R. Gentry, M.J. Bock, J.L. Lyndall, M.C. Capdevielle, and B.P. Slezak. 2017. Evaluation of triclosan in Minnesota lakes and rivers: Part II – human health risk assessment. <i>Ecotoxicology and Environmental Safety </i>142: 588-596. </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.0pt;font-family:"Times New Roman",serif;color:black">► </span><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black">Environmental concentrations of antibiotics impair zebrafish gut health </span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:9.0pt;font-family:"Franklin Gothic Medium Cond",sans-serif;color:black"> </span></p><p class="MsoNormal"><span style="font-size:8.5pt;font-family:"Franklin Gothic Book",sans-serif;color:black">Zhou, L., S.M. Limbu, M. Shen, et al. 2018. Environmental concentrations of antibiotics impair zebrafish gut health. <i>Environmental Pollution </i>235:245-254. </span><span style="font-size:10.0pt;font-family:"Georgia",serif"></span></p><p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Georgia",serif"> </span></p><p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Georgia",serif"> </span></p><p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#0000cc"> </span></p></div></body></html>