[Pharmwaste] Study on Environmental Factors Linked To Breast Cancer

Wed Jun 6 07:37:24 EDT 2007


Susan G. Komen for the Cure Commissions Study on Environmental Factors
Linked To Breast Cancer 

Study Results Published in Cancer; Free Access Available to Mammary
Carcinogens Database

DALLAS - May 14, 2007 - Susan G. Komen for the Cure and the Silent
Spring Institute announce the publication of Environmental Factors in
Breast Cancer, the most comprehensive review to date of scientific
research on environmental factors that may increase breast cancer risk.
The study findings were released today in the online version of the
scientific journal Cancer. A hard copy version of the study will be
published as a supplement to the June 15 edition of Cancer.

The state-of-the-science review, commissioned by Komen for the Cure and
conducted by the Silent Spring Institute with additional researchers
from Harvard University, Roswell Park Cancer Institute and the
University of Southern California, collected and assessed existing
scientific reports on potential links between specific environmental
factors and breast cancer. 

Researchers identify 216 chemicals that cause breast cancer in animals
The researchers synthesized national and international data sources and
identified 216 chemicals that cause breast tumors in animals. They used
the information to create a unique searchable online database featuring
detailed information on the carcinogens.

Free, searchable online database - carcinogens
The database, accessible at www.komen.org/environment, is available free
of charge and will be of particular interest to researchers, healthcare
workers, policymakers and some members of the public.

Komen's goal in funding the initiative
Komen for the Cure's goal in funding the Silent Spring initiative was to
determine where there is consensus within the scientific community on
the relationship between environmental factors and breast cancer and
where additional research or improved research methods are needed. Such
information can help guide public policy and help funding organizations
like Komen for the Cure to determine where to most effectively target
research grant monies.

Study details
The database includes references to 900 studies, 460 of which are human
breast cancer studies that were critically evaluated by the research
team. The studies measure breast cancer risk related to body size,
physical activity, environmental pollutants, and prospective studies of
diet. For each study, bibliographic information, key methods and
findings, and a critical assessment of the strength of the evidence is

The database reveals that among the 216 compounds that cause breast
tumors in animals:

-- 73 have been present in consumer products or as contaminants in food

-- 35 are air pollutants

-- 25 have been associated with occupational exposures affecting more
than 5,000 women a year

-- 29 are produced in the United States in large amounts, often
exceeding 1 million pounds per year.

"Komen is eager to see quality science yield answers that will
eventually lead us to our ultimate goal of knowing how to prevent breast
cancer. Commissioning this study is a step toward that goal, because it
helps to determine what is known and what is not known about the
possible link between certain environmental factors and the incidence of
breast cancer," said Hala Moddelmog, president and CEO of Komen for the

"While it is disturbing to learn that there are so many chemicals that
may be linked to breast cancer, there is also a great opportunity to
save thousands of lives by identifying those links, limiting exposure
and finding safer alternatives. It is critical that we integrate this
information into policies that govern chemical exposures," said Julia G.
Brody, PhD, executive director of the Silent Spring Institute.

Silent Spring Institute examines lifestyle influences
The Silent Spring Institute study also examined lifestyle influences on
breast cancer, such as physical activity and diet. The study results
underscore the importance of regular, life-long physical activity to
lower a woman's risk of developing breast cancer. The study concluded
that further research is needed to determine the relationship between
dietary factors and breast cancer risk.

Komen funds additional environmental projects
In response to the study's findings, Komen is now funding the
development of new and innovative models for researching breast cancer
and environmental risk factors. Komen also continues to fund
environmental projects as part of its investigator-initiated grants
program and is actively looking for ways to partner with other research
groups such as the U.S. Centers for Disease Control and Prevention
Environmental Health Labs.

Susan G. Komen for the Cure is committed to continuing its involvement
in the investigation of environmental factors related to breast cancer
and is funding a second phase of the Silent Spring Institute study.
Phase two focuses on the toxicology of endocrine disruptors, perinatal
and early life exposures, non-hormonal pharmaceuticals, tobacco smoke,
occupational exposures, exposure to light at night, and stress and
social factors.

"As an advocacy organization, Komen for the Cure is committed to
educating people about what we know about breast cancer today, while
continuously searching for evidence that will provide answers for
tomorrow," said Moddelmog.

Cancer is a journal of the American Cancer Society.

About Silent Spring Institute
Founded in 1994, Silent Spring Institute is a non-profit research
organization dedicated to studying the environment's effect on women's
health, with an emphasis on breast cancer. Silent Spring's
groundbreaking research on endocrine disrupting compounds and pollution
in homes has been published in Environmental Science & Technology,
Environmental Health Perspectives, and other scientific journals. Silent
Spring Institute scientists work in partnership with physicians and
public health advocates, and researchers at Brown University, Harvard
University, SUNY- Stony Brook, and elsewhere. Funding for Silent Spring
Institute's research is by grants from the National Institutes of
Health, National Science Foundation, private foundations, and individual
donors. For more information, please visit www.silentspring.org
<http://www.silentspring.org/> .


Steven Boggs; IDEM/OPPTA


800/988-7901 or 233-6660

Fax: 317/233-5627

100 N. Senate Ave, MC 64-01

Indianapolis, IN 46204-2251


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