[Pharmwaste] Excretion info: Aprepitant (Emend from Merck)

Gressitt, Stevan Stevan.Gressitt at maine.gov
Wed Feb 10 11:04:20 EST 2010


I would not interpret that way, but then something doesn't look right
about those numbers...Someone else should weigh in on what appears to be
a significant discrepancy on the face of it with a better explanation. 

 

Stevan Gressitt, M.D., Medical Director

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________________________________

From: pharmwaste-bounces at lists.dep.state.fl.us
[mailto:pharmwaste-bounces at lists.dep.state.fl.us] On Behalf Of Terri
Buckner
Sent: Wednesday, February 10, 2010 11:00 AM
To: pharmwaste at lists.dep.state.fl.us
Subject: [Pharmwaste] Excretion info: Aprepitant (Emend from Merck)

 

The patient info sheet, Metabolism section, from this drug says:

Following administration of a single IV 100-mg dose of [14C]-aprepitant
prodrug to healthy subjects, 57% of the radioactivity was recovered in
urine and 45% in feces. A study was not conducted with radiolabeled
capsule formulation.

Does this mean that 43% is excreted in urine and 55% in feces?

This is a drug used by cancer patients for nausea control. 

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