<html xmlns:v="urn:schemas-microsoft-com:vml" xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns:x="urn:schemas-microsoft-com:office:excel" xmlns:p="urn:schemas-microsoft-com:office:powerpoint" xmlns:a="urn:schemas-microsoft-com:office:access" xmlns:dt="uuid:C2F41010-65B3-11d1-A29F-00AA00C14882" xmlns:s="uuid:BDC6E3F0-6DA3-11d1-A2A3-00AA00C14882" xmlns:rs="urn:schemas-microsoft-com:rowset" xmlns:z="#RowsetSchema" xmlns:b="urn:schemas-microsoft-com:office:publisher" xmlns:ss="urn:schemas-microsoft-com:office:spreadsheet" xmlns:c="urn:schemas-microsoft-com:office:component:spreadsheet" xmlns:odc="urn:schemas-microsoft-com:office:odc" xmlns:oa="urn:schemas-microsoft-com:office:activation" xmlns:html="http://www.w3.org/TR/REC-html40" xmlns:q="http://schemas.xmlsoap.org/soap/envelope/" xmlns:rtc="http://microsoft.com/officenet/conferencing" xmlns:D="DAV:" xmlns:Repl="http://schemas.microsoft.com/repl/" xmlns:mt="http://schemas.microsoft.com/sharepoint/soap/meetings/" xmlns:x2="http://schemas.microsoft.com/office/excel/2003/xml" xmlns:ppda="http://www.passport.com/NameSpace.xsd" xmlns:ois="http://schemas.microsoft.com/sharepoint/soap/ois/" xmlns:dir="http://schemas.microsoft.com/sharepoint/soap/directory/" xmlns:ds="http://www.w3.org/2000/09/xmldsig#" xmlns:dsp="http://schemas.microsoft.com/sharepoint/dsp" xmlns:udc="http://schemas.microsoft.com/data/udc" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:sub="http://schemas.microsoft.com/sharepoint/soap/2002/1/alerts/" xmlns:ec="http://www.w3.org/2001/04/xmlenc#" xmlns:sp="http://schemas.microsoft.com/sharepoint/" xmlns:sps="http://schemas.microsoft.com/sharepoint/soap/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:udcs="http://schemas.microsoft.com/data/udc/soap" xmlns:udcxf="http://schemas.microsoft.com/data/udc/xmlfile" xmlns:udcp2p="http://schemas.microsoft.com/data/udc/parttopart" xmlns:wf="http://schemas.microsoft.com/sharepoint/soap/workflow/" xmlns:dsss="http://schemas.microsoft.com/office/2006/digsig-setup" xmlns:dssi="http://schemas.microsoft.com/office/2006/digsig" xmlns:mdssi="http://schemas.openxmlformats.org/package/2006/digital-signature" xmlns:mver="http://schemas.openxmlformats.org/markup-compatibility/2006" xmlns:m="http://schemas.microsoft.com/office/2004/12/omml" xmlns:mrels="http://schemas.openxmlformats.org/package/2006/relationships" xmlns:spwp="http://microsoft.com/sharepoint/webpartpages" xmlns:ex12t="http://schemas.microsoft.com/exchange/services/2006/types" xmlns:ex12m="http://schemas.microsoft.com/exchange/services/2006/messages" xmlns:pptsl="http://schemas.microsoft.com/sharepoint/soap/SlideLibrary/" xmlns:spsl="http://microsoft.com/webservices/SharePointPortalServer/PublishedLinksService" xmlns:Z="urn:schemas-microsoft-com:" xmlns:st="&#1;" xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv="Content-Type" content="text/html; charset=us-ascii">
<meta name="Generator" content="Microsoft Word 12 (filtered medium)">
<style><!--
/* Font Definitions */
@font-face
        {font-family:Wingdings;
        panose-1:5 0 0 0 0 0 0 0 0 0;}
@font-face
        {font-family:Wingdings;
        panose-1:5 0 0 0 0 0 0 0 0 0;}
@font-face
        {font-family:Calibri;
        panose-1:2 15 5 2 2 2 4 3 2 4;}
@font-face
        {font-family:Georgia;
        panose-1:2 4 5 2 5 4 5 2 3 3;}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
        {margin:0in;
        margin-bottom:.0001pt;
        font-size:11.0pt;
        font-family:"Calibri","sans-serif";}
a:link, span.MsoHyperlink
        {mso-style-priority:99;
        color:blue;
        text-decoration:underline;}
a:visited, span.MsoHyperlinkFollowed
        {mso-style-priority:99;
        color:purple;
        text-decoration:underline;}
span.EmailStyle17
        {mso-style-type:personal-compose;
        font-family:"Times New Roman","serif";
        color:#000099;}
span.datestamp2
        {mso-style-name:datestamp2;}
span.commentscontainer2
        {mso-style-name:comments_container2;}
.MsoChpDefault
        {mso-style-type:export-only;}
@page WordSection1
        {size:8.5in 11.0in;
        margin:1.0in 1.0in 1.0in 1.0in;}
div.WordSection1
        {page:WordSection1;}
/* List Definitions */
@list l0
        {mso-list-id:39978381;
        mso-list-template-ids:631298944;}
@list l0:level1
        {mso-level-number-format:bullet;
        mso-level-text:\F0B7;
        mso-level-tab-stop:.5in;
        mso-level-number-position:left;
        text-indent:-.25in;
        mso-ansi-font-size:10.0pt;
        font-family:Symbol;}
ol
        {margin-bottom:0in;}
ul
        {margin-bottom:0in;}
--></style><!--[if gte mso 9]><xml>
<o:shapedefaults v:ext="edit" spidmax="1026" />
</xml><![endif]--><!--[if gte mso 9]><xml>
<o:shapelayout v:ext="edit">
<o:idmap v:ext="edit" data="1" />
</o:shapelayout></xml><![endif]-->
</head>
<body lang="EN-US" link="blue" vlink="purple">
<div class="WordSection1">
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:#000099"><a href="http://www.bloomberg.com/news/2012-06-06/prozac-contaminated-drinking-water-may-be-link-to-autism.html">http://www.bloomberg.com/news/2012-06-06/prozac-contaminated-drinking-water-may-be-link-to-autism.html</a><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:#000099"><o:p>&nbsp;</o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;margin-bottom:9.0pt;mso-line-height-alt:15.6pt">
<b><span style="font-size:22.5pt;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;;color:#333333">Prozac-Contaminated Drinking Water May Be Link to Autism<o:p></o:p></span></b></p>
<p class="MsoNormal"><cite><span style="font-size:8.5pt;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;;color:#6F6F6F;font-style:normal">By Drew Armstrong -
</span></cite><span class="datestamp2"><span style="font-size:8.5pt;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;;color:#6F6F6F">Jun 7, 2012 12:00 AM ET</span></span><cite><span style="font-size:8.5pt;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;;color:#6F6F6F;font-style:normal">
</span></cite><span style="font-size:10.5pt;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;;color:#333333"><o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;margin-bottom:12.75pt;line-height:19.2pt">
<span style="font-size:11.5pt;font-family:&quot;Georgia&quot;,&quot;serif&quot;;color:#333333">Fish exposed to psychiatric medicines showed gene patterns similar to those found in people with autism, in a study suggesting a link between drugs that get into the human water supply
 and the brain development disorder. <o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;margin-bottom:12.75pt;line-height:19.2pt">
<span style="font-size:11.5pt;font-family:&quot;Georgia&quot;,&quot;serif&quot;;color:#333333">Researchers put antidepressants Prozac and Effexor, as well as antiseizure drug Tegratol into water tanks of minnows. Tests showed that the same genes turned on in people with autism
 were also triggered in the fish after exposure, according to a <a href="http://dx.plos.org/10.1371/journal.pone.0032917" title="Open Web Site">
study</a> published in the journal PLoS ONE. <o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;margin-bottom:12.75pt;line-height:19.2pt">
<span style="font-size:11.5pt;font-family:&quot;Georgia&quot;,&quot;serif&quot;;color:#333333">The findings suggest that small amounts of psychiatric medications found in the drinking supply may be a cause of autism, the researchers said. Psychiatric drugs have been linked to
 autism-like symptoms in studies of rats exposed to the medicines, according to the study.
<o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;margin-bottom:12.75pt;line-height:19.2pt">
<span style="font-size:11.5pt;font-family:&quot;Georgia&quot;,&quot;serif&quot;;color:#333333">&#8220;An environmental cause is really not on the radar for a lot of people,&#8221; said study author
<a href="http://www.isu.edu/bios/Professors_Staff/thomas_m.shtml" title="Open Web Site">
Michael Thomas</a>, a professor of evolutionary biology at Idaho State University in Pocatello, in a telephone interview. &#8220;My sincere hope is that this opens the door to a new question and allows people to look into that possibility.&#8221;
<o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;margin-bottom:12.75pt;line-height:19.2pt">
<span style="font-size:11.5pt;font-family:&quot;Georgia&quot;,&quot;serif&quot;;color:#333333">Concentrations of the drugs are found downstream from water treatment plants that process human waste that contains the medicines, Thomas said. The molecules make their way into the
 supply downstream, where pregnant mothers who drink the water can pass the exposure to their fetuses.
<o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;margin-bottom:12.75pt;line-height:19.2pt">
<span style="font-size:11.5pt;font-family:&quot;Georgia&quot;,&quot;serif&quot;;color:#333333">&#8220;While others have envisioned a causal role for psychotropic drugs in idiopathic autism, we were astonished to find evidence that this might occur at very low dosages, such as those
 found in aquatic systems,&#8221; Thomas said in a statement accompanying the study. <o:p>
</o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;margin-bottom:12.75pt;line-height:19.2pt">
<span style="font-size:11.5pt;font-family:&quot;Georgia&quot;,&quot;serif&quot;;color:#333333">Eli Lilly &amp; Co.&#8217;s Prozac, Pfizer Inc.&#8217;s Effexor and their generic equivalents belong to classes of drugs that generated $14.2 billion in U.S. sales last year, according to data compiled
 by Wolters Kluwer NV and Bloomberg. <o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;margin-bottom:12.75pt;line-height:19.2pt">
<b><span style="font-size:11.5pt;font-family:&quot;Georgia&quot;,&quot;serif&quot;;color:#333333">Higher Concentrations
<o:p></o:p></span></b></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;margin-bottom:12.75pt;line-height:19.2pt">
<span style="font-size:11.5pt;font-family:&quot;Georgia&quot;,&quot;serif&quot;;color:#333333">The researchers used concentrations of the drugs higher than are measured in the field, which Thomas said was intentional.
<o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;margin-bottom:12.75pt;line-height:19.2pt">
<span style="font-size:11.5pt;font-family:&quot;Georgia&quot;,&quot;serif&quot;;color:#333333">&#8220;Every study that comes out that measures concentrations in the environment shows orders of magnitude higher than the previous study, so we figured the concentrations would catch up
 with us,&#8221; Thomas said. <o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;margin-bottom:12.75pt;line-height:19.2pt">
<span style="font-size:11.5pt;font-family:&quot;Georgia&quot;,&quot;serif&quot;;color:#333333">The researchers are collecting water samples from places with known concentrations, and plan to test minnows in that water, he said.
<o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;margin-bottom:12.75pt;line-height:19.2pt">
<b><span style="font-size:11.5pt;font-family:&quot;Georgia&quot;,&quot;serif&quot;;color:#333333">Autism Rise
<o:p></o:p></span></b></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;margin-bottom:12.75pt;line-height:19.2pt">
<span style="font-size:11.5pt;font-family:&quot;Georgia&quot;,&quot;serif&quot;;color:#333333">The number of children with autism and related disorders is rising, according to data collected by the U.S.
<a href="http://www.cdc.gov/ncbddd/autism/data.html" title="Open Web Site">Centers for Disease Control and Prevention</a> in Atlanta. The number of 8-year- olds identified with autism spectrum disorders rose 23 percent in 2008 from 2006, according to a March
 CDC report. Some of the increase is due to a higher awareness of autism as a cause of behavioral disorders, though how much that contributed to the rise isn&#8217;t known, according to the report.
<o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;margin-bottom:12.75pt;line-height:19.2pt">
<span style="font-size:11.5pt;font-family:&quot;Georgia&quot;,&quot;serif&quot;;color:#333333">Autism includes a range of disorders characterized by social impairment, communication difficulties, and restricted, repetitive patterns of behavior, according to the
<a href="http://topics.bloomberg.com/national-institutes-of-health/">National Institutes of Health</a>.
<o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;margin-bottom:12.75pt;line-height:19.2pt">
<span style="font-size:11.5pt;font-family:&quot;Georgia&quot;,&quot;serif&quot;;color:#333333">The study was supported by funding from the PhRMA Foundation, National Institutes of Health and Idaho State University.
<o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;margin-bottom:12.75pt;line-height:19.2pt">
<span style="font-size:11.5pt;font-family:&quot;Georgia&quot;,&quot;serif&quot;;color:#333333">To contact the reporter on this story: Drew Armstrong in
<a href="http://topics.bloomberg.com/new-york/">New York</a> at <a href="mailto:darmstrong17@bloomberg.net" title="Send E-mail">
darmstrong17@bloomberg.net</a>; <o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;margin-bottom:12.75pt;line-height:19.2pt">
<span style="font-size:11.5pt;font-family:&quot;Georgia&quot;,&quot;serif&quot;;color:#333333">To contact the editor responsible for this story: Reg Gale at
<a href="mailto:rgale5@bloomberg.net" title="Send E-mail">rgale5@bloomberg.net</a>
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:#000099"><o:p>&nbsp;</o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy">Deborah L. DeBiasi</span><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy"><br>
</span><b><span style="font-size:10.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy">Email: &nbsp;&nbsp;Deborah.DeBiasi@deq.virginia.gov</span></b><b><i><span style="font-size:10.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:red"><br>
</span></i></b><span style="font-size:10.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy">WEB site address:&nbsp;
<a href="http://www.deq.virginia.gov/">www.deq.virginia.gov</a></span><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy"><br>
</span><span style="font-size:10.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy">Virginia Department of Environmental Quality</span><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy"><br>
</span><span style="font-size:10.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy">Office of Water Permit and Compliance Assistance Programs</span><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy"><br>
</span><span style="font-size:10.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy">Industrial Pretreatment/Whole Effluent Toxicity (WET) Program</span><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy"><br>
</span><span style="font-size:10.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy">PPCPs, EDCs, and Microconstituents</span><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy">&nbsp;
<a href="http://www.deq.virginia.gov/Programs/Water/PermittingCompliance/PollutionDischargeElimination/Microconstituents.aspx">
http://www.deq.virginia.gov/Programs/Water/PermittingCompliance/PollutionDischargeElimination/Microconstituents.aspx</a></span><span style="font-size:10.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy">Mail:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; P.O. Box 1105, Richmond, VA&nbsp; 23218</span><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy"><br>
</span><span style="font-size:10.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy">Location:&nbsp; 629 E. Main Street, Richmond, VA&nbsp; 23219</span><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy"><br>
</span><span style="font-size:10.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy">PH:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;804-698-4028&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; FAX: &nbsp;&nbsp;&nbsp;&nbsp; 804-698-4032</span><span style="font-size:10.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:#000099"><o:p></o:p></span></p>
<p class="MsoNormal"><o:p>&nbsp;</o:p></p>
</div>
</body>
</html>