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<p class="MsoNormal" style="line-height:16.5pt;background:white"><b><span lang="EN-GB" style="font-size:15.0pt;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;;color:black">EPA Lists Chemicals For EDSP Screening
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<p class="MsoNormal" style="line-height:19.2pt;background:white"><b><span lang="EN-GB" style="font-size:8.5pt;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;;color:#949494">Posted: November 28, 2012
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<span lang="EN-GB" style="font-size:9.0pt;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;;color:black">EPA has released the list of roughly 10,000 chemicals that it anticipates will eventually undergo screening for potential developmental risks as part of its Endocrine Disruptor
 Screening Program (EDSP), following repeated calls from the agency's Inspector General (IG) seeking such a list.<o:p></o:p></span></p>
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<span lang="EN-GB" style="font-size:9.0pt;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;;color:black">The
<a href="http://insideepa.com/iwpfile.html?file=nov2012%2Fepa2012_2164.pdf"><span style="color:black">list and accompanying white paper</span></a> follow requests from the IG last year that EPA estimate the number of chemicals that should undergo EDSP screening,
 in order to better manage the long-stalled and often controversial program. Congress mandated EPA create such a program in the 1996 Food Quality Protection Act, but it was not until 2009 that EPA issued the first test orders to chemicals to undergo EDSP screening.<o:p></o:p></span></p>
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<span lang="EN-GB" style="font-size:9.0pt;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;;color:black">The list and white paper represent an early step in the &quot;EDSP Comprehensive Management Plan&quot; the agency
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<span style="color:black">released last summer</span></a>, where it indicated that it would issue in fiscal year 2013 its long-delayed list of drinking water contaminants it plans to test. The list of chemicals are to be addressed during the five-year time
 frame of the EDSP management plan. EPA drafted the plan in response to critical IG reports last year. A May 2011 IG report faulted the agency for taking longer than a decade to create the screening program and blamed part of the program's delays on mismanagement,
 arguing that there was no management plan for the program's operation.<o:p></o:p></span></p>
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<span lang="EN-GB" style="font-size:9.0pt;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;;color:black">In a follow-up report, the agency watchdog said last December that it needed &quot;additional information and clarification&quot; on agency plans to define the possible universe of
 chemicals that could be considered for screening in EDSP. The IG also sought agency plans to describe how it will prioritize chemicals to be included in the EDSP in the future.<o:p></o:p></span></p>
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<span lang="EN-GB" style="font-size:9.0pt;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;;color:black">EPA's list contains roughly 10,000 chemicals gleaned from its Federal Food Drug and Cosmetic Act (FFDCA) and Safe Drinking Water Act (SDWA) authorities. EPA estimates there
 are roughly 5,000 pesticide ingredients, 90 SDWA regulated contaminants and 6,000 chemicals that are currently unregulated under SDWA but may be drinking water contaminants -- all of which could be considered for EDSP screening.<o:p></o:p></span></p>
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<span lang="EN-GB" style="font-size:9.0pt;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;;color:black">EPA's new white paper explains that &#8220;the agency plans to develop a prioritization scheme built on the broader, general concept articulated in the National Academy of Sciences
 Toxicity Testing in the Twenty-first Century: A Vision and a Strategy, which speaks to the need to integrate all existing knowledge and multiple tools to generate a more practical, scientifically-based prioritized list of chemicals for EDSP screening. These
 prioritization tools include the consideration of physicochemical properties (e.g., exclusions of polymers, strong acids and bases, reactive and unstable compounds, undefined chemicals like coconut, oils and kaolin, etc.), structure activity relationship and
 high-throughput computational methods.&#8221;<o:p></o:p></span></p>
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<span lang="EN-GB" style="font-size:9.0pt;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;;color:black">The agency
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<span style="color:black">announced earlier this month</span></a> that its Science Advisory Panel (SAP) will meet in Arlington, VA, Jan. 29 - Feb. 1 to review the agency's prioritization plan for chemicals to undergo EDSP screening. The plan, according to the
 Nov. 16 <i>Federal Register</i> notice, aims to use computational methods such as high-throughput screening and modeling to help &quot;focus the generation of new data on chemicals that are more likely to have the potential to interact with the estrogen, androgen,
 or thyroid pathways.&#8221;<o:p></o:p></span></p>
<p class="MsoNormal" style="line-height:12.0pt;background:white"><span lang="EN-GB" style="font-size:9.0pt;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;;color:black">The new white paper provides the &#8220;'validation principles' that the agency will use in the development and
 implementation of a chemical prioritization approach based on computational toxicology tools,&#8221; for prioritizing the 10,000 chemicals for EDSP screening. EPA explains that its validation approach is based on one published by the international Organisation for
 Economic Co-operation and Development several years ago. The process is intended to result in a prioritization tool that has &#8220;a defined endpoint, an unambiguous algorithm, a defined domain of applicability an appropriate measures of goodness-of-fit, robustness
 and predictivity and a mechanistic interpretation.&#8221;<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy">Deborah L. DeBiasi</span><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy"><br>
</span><b><span style="font-size:10.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy">Email: &nbsp;&nbsp;Deborah.DeBiasi@deq.virginia.gov</span></b><b><i><span style="font-size:10.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:red"><br>
</span></i></b><span style="font-size:10.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy">WEB site address:&nbsp;
<a href="http://www.deq.virginia.gov/">www.deq.virginia.gov</a></span><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy"><br>
</span><span style="font-size:10.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy">Virginia Department of Environmental Quality</span><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy"><br>
</span><span style="font-size:10.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy">Office of Water Permit and Compliance Assistance Programs</span><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy"><br>
</span><span style="font-size:10.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy">Industrial Pretreatment/Whole Effluent Toxicity (WET) Program</span><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy"><br>
</span><span style="font-size:10.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy">PPCPs, EDCs, and Microconstituents</span><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy">&nbsp;
<a href="http://www.deq.virginia.gov/Programs/Water/PermittingCompliance/PollutionDischargeElimination/Microconstituents.aspx">
http://www.deq.virginia.gov/Programs/Water/PermittingCompliance/PollutionDischargeElimination/Microconstituents.aspx</a></span><span style="font-size:10.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy">Mail:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; P.O. Box 1105, Richmond, VA&nbsp; 23218</span><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy"><br>
</span><span style="font-size:10.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy">Location:&nbsp; 629 E. Main Street, Richmond, VA&nbsp; 23219</span><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy"><br>
</span><span style="font-size:10.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:navy">PH:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;804-698-4028&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; FAX: &nbsp;&nbsp;&nbsp;&nbsp; 804-698-4032<o:p></o:p></span></p>
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