[Pharmwaste] Excretion info: Aprepitant (Emend from Merck)

[Sue Dayton]

Jacob:

 

Can you tell me what happens to meperidine (and what is it) after it is
metabolized and released? Do you have any information on the number of drugs
that go through this same process that result in a more toxic compound being
released? 

 

Sue Dayton

Blue Ridge Environmental Defense League

North Carolina Healthy Communities Program

PO BOX 44

Saxapahaw, NC 27340

(336) 525-2003

sdayton at swcp.com

 

 

 

Our lives begin to end the day we become silent about things that matter.
-  Martin Luther King Jr.

 

 

 

  _____  

From: pharmwaste-bounces at lists.dep.state.fl.us
[mailto:pharmwaste-bounces at lists.dep.state.fl.us] On Behalf Of Jacob Hutti
Sent: Wednesday, February 10, 2010 11:11 AM
To: Terri Buckner; pharmwaste at lists.dep.state.fl.us
Subject: RE: [Pharmwaste] Excretion info: Aprepitant (Emend from Merck)

 

NO. the other way around.. They captured 57%  recovered in urine and 45% in
feces. this only happens if a drug is removed unchanged from the body.

A much more complicated question remains.what happens when a body actually
changes the drug and then excretes these other changed chemicals!!! This is
the problem with meperidine and hundreds of other drugs.. The metabolite of
meperidine is MUCH more toxic that the parent compound . 

 

Whether any drug is returned to the earth in any fashion the vast majority
that needs to be addressed is the volume that is taken or administered or
excreted in any form. It is absurd to try and address the miniscule % that
happens to go out of date on a shelf as a significant problem in the overall
view of biomass being returned to the earth.

 

Jacob Hutti, Pharm.D.

V.P. Business Development

PCA Pharmacy

1-866-213-8361

 

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From: pharmwaste-bounces at lists.dep.state.fl.us
[mailto:pharmwaste-bounces at lists.dep.state.fl.us] On Behalf Of Terri Buckner
Sent: Wednesday, February 10, 2010 11:00 AM
To: pharmwaste at lists.dep.state.fl.us
Subject: [Pharmwaste] Excretion info: Aprepitant (Emend from Merck)

 

The patient info sheet, Metabolism section, from this drug says:

Following administration of a single IV 100-mg dose of [14C]-aprepitant
prodrug to healthy subjects, 57% of the radioactivity was recovered in urine
and 45% in feces. A study was not conducted with radiolabeled capsule
formulation.

Does this mean that 43% is excreted in urine and 55% in feces?

This is a drug used by cancer patients for nausea control. 

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