[Pharmwaste] FW: Bisphenol A's 'twin' may have more potent hormone effects

[Tenace, Laurie]

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From: Cecilia Height [mailto:cheight at cfl.rr.com]
Sent: Friday, May 14, 2010 2:25 AM
To: pharmwaste-bounces at lists.dep.state.fl.us
Subject: Bisphenol A's 'twin' may have more potent hormone effects


http://www.sciencenews.org/view/generic/id/59113/title/Another_plastics_ingredient_raises_safety_concerns_
Another plastics ingredient raises safety concerns
Bisphenol A's 'twin' may have more potent hormone effects
By Janet Raloff<http://www.sciencenews.org/view/authored/id/18/name/Janet_Raloff>
Web edition : Wednesday, May 12th, 2010
Nonidentical twinsBPA's structure resembles a pair of spectacles with two methyl, or CH3, groups dangling from its bridge. In BPAF, the methyl groups' hydrogen atoms are substituted with fluorines.NIEHS

A largely ignored contaminant doesn't just resemble bisphenol A, the chemical found to leach out of hard plastic water bottles. It's BPA's fluorinated twin - on steroids.

New laboratory studies in Japan indicate that the twin, called bisphenol AF, or BPAF, may be even more potent than BPA in altering the effects of steroid hormones such as estrogens in the body.

The unusual way that BPAF blocks some estrogen actions and fosters others "could make this a vicious compound, a very toxic compound," says Jan-Åke Gustafsson, a molecular endocrinologist at the University of Houston. The chemical is an ingredient of many plastics, electronic devices, optical fibers and more.

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