[Pharmwaste] Endocrine disruptors impair human sperm function, research finds

[DeBiasi, Deborah (DEQ)]

http://www.sciencedaily.com/releases/2014/05/140512101410.htm

Endocrine disruptors impair human sperm function, research finds
Date:
May 12, 2014
Source:
EMBO - excellence in life sciences
Summary:
A plethora of endocrine-disrupting chemicals interfere with human sperm function in a way that may have a negative impact on fertilization, according to new research. The work suggests that endocrine disruptors may contribute to widespread fertility problems in the Western world in a way that hitherto has not been recognized.
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[http://images.sciencedaily.com/2014/05/140512101410-large.jpg]
Illustration of sperm (stock image). A plethora of endocrine-disrupting chemicals interfere with human sperm function in a way that may have a negative impact on fertilization.
Credit: © idambeer / Fotolia
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Illustration of sperm (stock image). A plethora of endocrine-disrupting chemicals interfere with human sperm function in a way that may have a negative impact on fertilization.
Credit: © idambeer / Fotolia
A plethora of endocrine-disrupting chemicals interfere with human sperm function in a way that may have a negative impact on fertilization. These are the findings of a German -- Danish team of researchers from the Center of Advanced European Studies and Research in Bonn, Germany, and the University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark. The work, which is published in EMBO reports, suggests that endocrine disruptors may contribute to widespread fertility problems in the Western world in a way that hitherto has not been recognized.
Endocrine disruptors are present in food, textiles, drugs, household, and personal-care products such as plastic bottles, toys, and cosmetics. Proving the deleterious effects of endocrine disruptors on human beings has been difficult due to a lack of suitable experimental systems.

The European Commission is currently reviewing its policy on endocrine-disrupting chemicals. Last year, their plans caused a debate between endocrinologists and a group of toxicologists over how to regulate these chemicals. "Our study provides scientific evidence to assist forming international rules and practices," said the leader of the study, Timo Strünker, from the Center of Advanced European Studies and Research in Bonn, Germany.

"For the first time, we have shown a direct link between exposure to endocrine disrupting chemicals from industrial products and adverse effects on human sperm function,'' said Niels E. Skakkebaek, professor and leader of the Danish team.

Hundreds to thousands of chemicals can be rapidly tested for their potential to interfere with human sperm function using the bioassay developed by the researchers. In this initial study, about one hundred chemicals were tested. Around one third, including ultraviolet (UV) filters like 4-methylbenzylidene camphor (4-MBC) used in some sunscreens, the anti-bacterial agent Triclosan used in toothpaste, and di-n-butylphthalate (DnBP), showed adverse actions.

The scientists looked at the impact of these chemicals on the CatSper ion channel, a calcium channel controlling sperm motility. They showed that endocrine disruptors -- applied at concentrations measured in body fluids -- directly open CatSper and, thereby, increase calcium levels in sperm, change their swimming behavior, and trigger the release of digestive enzymes that help sperm to break through the egg coat. Moreover, endocrine disruptors render sperm less sensitive for progesterone and prostaglandins -- two important hormones released by cells surrounding the egg. Finally, the authors noted that in low-dose mixtures, the chemicals cooperate to elevate calcium levels in sperm.

Altogether, the study indicates that endocrine disruptors might disturb the precisely coordinated sequence of events underlying fertilization in several ways: the chemicals might evoke changes in swimming behaviour at the wrong time and wrong place, hinder navigation of sperm towards the egg, and hamper penetration into the protective egg coat.

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Story Source:
The above story is based on materials<http://www.embo.org/news/research-news/research-news-2014/endocrine-disruptors-impair-human-sperm-function> provided by EMBO - excellence in life sciences<http://www.embo.org>. Note: Materials may be edited for content and length.
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Journal Reference:
1.       Schiffer C, Müller A, Egeberg DL, Brenker C, Rehfeld A, Frederiksen H, Wäschle B, Kaupp UB, Balbach M, Wachten D, Skakkebaek NE, Almstrup K, Strünker T. Direct action of endocrine disrupting chemicals on human sperm. EMBOreports, 2014 DOI: 10.15252/embr.201438869<http://dx.doi.org/10.15252/embr.201438869>
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[*]
EMBO - excellence in life sciences. "Endocrine disruptors impair human sperm function, research finds." ScienceDaily. ScienceDaily, 12 May 2014. <www.sciencedaily.com/releases/2014/05/140512101410.htm>.


Deborah L. DeBiasi
Email:   Deborah.DeBiasi at deq.virginia.gov
WEB site address:  www.deq.virginia.gov<http://www.deq.virginia.gov/>
Virginia Department of Environmental Quality
Office of Water Permits
Industrial Pretreatment/Whole Effluent Toxicity (WET) Program
PPCPs, EDCs, and Microconstituents
http://www.deq.virginia.gov/Programs/Water/PermittingCompliance/PollutionDischargeElimination/Microconstituents.aspx
Mail:          P.O. Box 1105, Richmond, VA  23218
Location:  629 E. Main Street, Richmond, VA  23219
PH:         804-698-4028      FAX:      804-698-4032

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