[Pharmwaste] excreted drugs & whole effluent toxicity?

[Gilliam, Allen]

Fellow Pharma folks,

Sorry for getting off the take-back programs for just a minute.

Maybe most of you have already seen this, but Dr. Christian Daughton recently authored this Eco-directed sustainable prescribing: feasibility for reducing water contamination by drugs @ http://dx.doi.org/10.1016/j.scitotenv.2014.06.013 .  Its abstract itself may take a few readings to understand (at least it did for me), but I believe the underlying concept of the manuscript is P2's source reduction.

I only briefly scanned several pages of its content and is way above this mechanical engineer's head.  For those of you familiar with pharmacokinetics, you may be able to glean some important themes in the Dr's contentions.

Add another acronym to your vocabulary if you haven't already because Biopharmaceutics Drug Disposition Classification System (BDDCS) runs throughout its core.

I would expect a brief synopsis from our dear friend, Dr. Charlotte Smith in a few weeks.

My original e-mail's intent to several experts on this issue was mainly to discover which analytical methods could be used to measure low level APIs (which method measure what APIs or their metabolites?); therefore, helping to determine if their presence could potentially be the toxicant(s) in cities' WET sublethality failures (growth and reproductivity).

Dr. Susan Glassmeyer, e-cc'd above was suggested as a good source by Dr. Daughton.   Dr. Glassmeyer?  Would you please respond in some manner?  I'd love for more cities to get involved with their own w.w. treatment plant's effluent quality.  Heretofore, most cities in the US are not sampling/analyzing for APIs or their metabolites.  At least I have seen very few reports about them except through the USGS.

Ciao,

Allen Gilliam
ADEQ State Pretreatment Coordinator
501.682.0625
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