[Pharmwaste] excreted drugs & whole effluent toxicity?

[Jim Mullowney]

What I took from Dr. Daughton's report is that the way to reduce the effects
of drugs in the environment is to lower the dose administered to the patient
because drugs are in the environment from human excretion. 

 

He further states:

 

"Certain drug classes (especially cytotoxic chemotherapeutics) may not be
amenable to this approach; the best control measure for such highly toxic
drugs may simply be the prevention of urine and feces from entering sewers"

 

There are 27 cytotoxic chemotherapy drugs that are heavily excreted (I
attached the list) and need to be collected for 48 hours after infusion
according to the World Health Organization. Go to www.cytotoxicsafety.com to
see how to easily control human waste with cytotoxic chemotherapy drugs.

 

 

Jim Mullowney

 

 

From: pharmwaste-bounces at lists.dep.state.fl.us
[mailto:pharmwaste-bounces at lists.dep.state.fl.us] On Behalf Of Gilliam,
Allen
Sent: Friday, September 12, 2014 10:41 AM
To: 'pharmwaste at lists.dep.state.fl.us'
Cc: Glassmeyer.susan at Epa.gov
Subject: [Pharmwaste] excreted drugs & whole effluent toxicity?

 

Fellow Pharma folks,

 

Sorry for getting off the take-back programs for just a minute.

 

Maybe most of you have already seen this, but Dr. Christian Daughton
recently authored this Eco-directed sustainable prescribing: feasibility for
reducing water contamination by drugs @
<http://dx.doi.org/10.1016/j.scitotenv.2014.06.013>
http://dx.doi.org/10.1016/j.scitotenv.2014.06.013 .  Its abstract itself may
take a few readings to understand (at least it did for me), but I believe
the underlying concept of the manuscript is P2's source reduction.

 

I only briefly scanned several pages of its content and is way above this
mechanical engineer's head.  For those of you familiar with
pharmacokinetics, you may be able to glean some important themes in the Dr's
contentions.  

 

Add another acronym to your vocabulary if you haven't already because
Biopharmaceutics Drug Disposition Classification System (BDDCS) runs
throughout its core.

 

I would expect a brief synopsis from our dear friend, Dr. Charlotte Smith in
a few weeks.

 

My original e-mail's intent to several experts on this issue was mainly to
discover which analytical methods could be used to measure low level APIs
(which method measure what APIs or their metabolites?); therefore, helping
to determine if their presence could potentially be the toxicant(s) in
cities' WET sublethality failures (growth and reproductivity).  

 

Dr. Susan Glassmeyer, e-cc'd above was suggested as a good source by Dr.
Daughton.   Dr. Glassmeyer?  Would you please respond in some manner?  I'd
love for more cities to get involved with their own w.w. treatment plant's
effluent quality.  Heretofore, most cities in the US are not
sampling/analyzing for APIs or their metabolites.  At least I have seen very
few reports about them except through the USGS.

 

Ciao,  

 

Allen Gilliam

ADEQ State Pretreatment Coordinator

501.682.0625

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