[Pharmwaste] Re: Pharmwaste Digest, Vol 107, Issue 21

[Ronald Ney]

I have yet to see data on metabolites secreted or degradation of parent and
metabolites in the environment by photodegradation, pH, microbial
degradation. Are there analytes for parent and degradation products? Have
the extraction methods be proven that parent and degradates can be
extracted over time and that they are not adsorbed in the media tested?

Ron Ney

On Sat, Sep 13, 2014 at 12:58 AM, <pharmwaste-request at lists.dep.state.fl.us>
wrote:

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> Today's Topics:
>
>    1. excreted drugs & whole effluent toxicity? (Gilliam, Allen)
>    2. NIOSH Updates Hazardous Drug List 2014 (Jeff Hollar)
>    3. RE: excreted drugs & whole effluent toxicity? (Jim Mullowney)
>
>
> ---------- Forwarded message ----------
> From: "Gilliam, Allen" <GILLIAM at adeq.state.ar.us>
> To: "'pharmwaste at lists.dep.state.fl.us'" <pharmwaste at lists.dep.state.fl.us
> >
> Cc: "Glassmeyer.susan at Epa.gov" <Glassmeyer.susan at epa.gov>
> Date: Fri, 12 Sep 2014 09:40:31 -0500
> Subject: [Pharmwaste] excreted drugs & whole effluent toxicity?
>
> Fellow Pharma folks,
>
>
>
> Sorry for getting off the take-back programs for just a minute.
>
>
>
> Maybe most of you have already seen this, but Dr. Christian Daughton
> recently authored this *Eco-directed sustainable prescribing: feasibility
> for reducing water contamination by drugs* @
> http://dx.doi.org/10.1016/j.scitotenv.2014.06.013 .  Its abstract itself
> may take a few readings to understand (at least it did for me), but I
> believe the underlying concept of the manuscript is P2’s source reduction.
>
>
>
> I only briefly scanned several pages of its content and is way above this
> mechanical engineer’s head.  For those of you familiar with
> pharmacokinetics, you may be able to glean some important themes in the
> Dr’s contentions.
>
>
>
> Add another acronym to your vocabulary if you haven’t already because
> Biopharmaceutics Drug Disposition Classification System (BDDCS) runs
> throughout its core.
>
>
>
> I would expect a brief synopsis from our dear friend, Dr. Charlotte Smith
> in a few weeks.
>
>
>
> My original e-mail’s intent to several experts on this issue was mainly to
> discover which analytical methods could be used to measure low level APIs
> (which method measure what APIs or their metabolites?); therefore, helping
> to determine if their presence could potentially be the toxicant(s) in
> cities’ WET sublethality failures (growth and reproductivity).
>
>
>
> Dr. Susan Glassmeyer, e-cc’d above was suggested as a good source by Dr.
> Daughton.   Dr. Glassmeyer?  Would you please respond in some manner?  I’d
> love for more cities to get involved with their own w.w. treatment plant’s
> effluent quality.  Heretofore, most cities in the US are not
> sampling/analyzing for APIs or their metabolites.  At least I have seen
> very few reports about them except through the USGS.
>
>
>
> Ciao,
>
>
>
> Allen Gilliam
>
> ADEQ State Pretreatment Coordinator
>
> 501.682.0625
>
>
> ---------- Forwarded message ----------
> From: Jeff Hollar <jhollar at pwaste.com>
> To: <pharmwaste at lists.dep.state.fl.us>
> Cc:
> Date: Fri, 12 Sep 2014 10:43:21 -0500
> Subject: [Pharmwaste] NIOSH Updates Hazardous Drug List 2014
>
> 27 new drugs added and 12 drugs removed.  We have incorporated these
> changes in our database.
>
>
>
> http://www.cdc.gov/niosh/docs/2014-138/pdfs/2014-138.pdf
>
>
>
> Jeff Hollar
>
> President
>
> *PharmWaste Technologies, Inc.*
>
> 4164 NW Urbandale Dr., Ste A
>
> Urbandale, IA 50322
>
> 515-276-5302 (general)
>
> 515-331-7310 (direct)
>
> 515-360-9785 (cell)
>
> www.pwaste.com
>
>
>
>
>
>
>
>
>
>
>
>
> ---------- Forwarded message ----------
> From: Jim Mullowney <jmullowney at pharma-cycle.com>
> To: "'Gilliam, Allen'" <GILLIAM at adeq.state.ar.us>, <
> pharmwaste at lists.dep.state.fl.us>
> Cc: Glassmeyer.susan at epa.gov
> Date: Fri, 12 Sep 2014 11:45:37 -0400
> Subject: RE: [Pharmwaste] excreted drugs & whole effluent toxicity?
>
> What I took from Dr. Daughton’s report is that the way to reduce the
> effects of drugs in the environment is to lower the dose administered to
> the patient because drugs are in the environment from human excretion.
>
>
>
> He further states:
>
>
>
> “Certain drug classes (especially cytotoxic chemotherapeutics) may not be
> amenable to this approach; the best control measure for such highly toxic
> drugs may simply be the prevention of urine and feces from entering sewers”
>
>
>
> There are 27 cytotoxic chemotherapy drugs that are heavily excreted (I
> attached the list) and need to be collected for 48 hours after infusion
> according to the World Health Organization. Go to www.cytotoxicsafety.com
> to see how to easily control human waste with cytotoxic chemotherapy drugs.
>
>
>
>
>
> Jim Mullowney
>
>
>
>
>
> *From:* pharmwaste-bounces at lists.dep.state.fl.us [mailto:
> pharmwaste-bounces at lists.dep.state.fl.us] *On Behalf Of *Gilliam, Allen
> *Sent:* Friday, September 12, 2014 10:41 AM
> *To:* 'pharmwaste at lists.dep.state.fl.us'
> *Cc:* Glassmeyer.susan at Epa.gov
> *Subject:* [Pharmwaste] excreted drugs & whole effluent toxicity?
>
>
>
> Fellow Pharma folks,
>
>
>
> Sorry for getting off the take-back programs for just a minute.
>
>
>
> Maybe most of you have already seen this, but Dr. Christian Daughton
> recently authored this *Eco-directed sustainable prescribing: feasibility
> for reducing water contamination by drugs* @
> http://dx.doi.org/10.1016/j.scitotenv.2014.06.013 .  Its abstract itself
> may take a few readings to understand (at least it did for me), but I
> believe the underlying concept of the manuscript is P2’s source reduction.
>
>
>
> I only briefly scanned several pages of its content and is way above this
> mechanical engineer’s head.  For those of you familiar with
> pharmacokinetics, you may be able to glean some important themes in the
> Dr’s contentions.
>
>
>
> Add another acronym to your vocabulary if you haven’t already because
> Biopharmaceutics Drug Disposition Classification System (BDDCS) runs
> throughout its core.
>
>
>
> I would expect a brief synopsis from our dear friend, Dr. Charlotte Smith
> in a few weeks.
>
>
>
> My original e-mail’s intent to several experts on this issue was mainly to
> discover which analytical methods could be used to measure low level APIs
> (which method measure what APIs or their metabolites?); therefore, helping
> to determine if their presence could potentially be the toxicant(s) in
> cities’ WET sublethality failures (growth and reproductivity).
>
>
>
> Dr. Susan Glassmeyer, e-cc’d above was suggested as a good source by Dr.
> Daughton.   Dr. Glassmeyer?  Would you please respond in some manner?  I’d
> love for more cities to get involved with their own w.w. treatment plant’s
> effluent quality.  Heretofore, most cities in the US are not
> sampling/analyzing for APIs or their metabolites.  At least I have seen
> very few reports about them except through the USGS.
>
>
>
> Ciao,
>
>
>
> Allen Gilliam
>
> ADEQ State Pretreatment Coordinator
>
> 501.682.0625
>
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