[Pharmwaste] Uptake of human pharmaceuticals in bull sharks (Carcharhinus leucas) inhabiting a wastewater-impacted river.

[Catherine Zimmer]

Uptake of human pharmaceuticals in bull sharks (Carcharhinus leucas)
inhabiting a wastewater-impacted river.


 
<https://www.ncbi.nlm.nih.gov/pubmed/?term=Gelsleichter%20J%5BAuthor%5D&caut
hor=true&cauthor_uid=23602972> Gelsleichter J1,
<https://www.ncbi.nlm.nih.gov/pubmed/?term=Szabo%20NJ%5BAuthor%5D&cauthor=tr
ue&cauthor_uid=23602972> Szabo NJ.

 <https://www.ncbi.nlm.nih.gov/pubmed/23602972> Sci Total Environ. 2013 Jul
1;456-457:196-201. doi: 10.1016/j.scitotenv.2013.03.078. Epub 2013 Apr 17.


Abstract


The presence of human pharmaceuticals in sewage-impacted ecosystems is a
growing concern that poses health risks to aquatic wildlife. Despite this,
few studies have investigated the uptake of active pharmaceutical
ingredients (APIs) in aquatic organisms. In this study, the uptake of 9 APIs
from human drugs was examined and compared in neonate bull sharks
(Carcharhinus leucas) residing in pristine (Myakka River) and
wastewater-impacted (Caloosahatchee River) tributaries of Florida's
Charlotte Harbor estuary. The synthetic estrogen used in human
contraceptives (17α-ethynylestradiol) and 6 of the selective
serotonin/norepinephrine reuptake inhibitors (citalopram, fluoxetine,
fluvoxamine, paroxetine, sertraline, venlafaxine) used in human
antidepressants were observed at detectable and, in some cases, quantifiable
levels in plasma of Caloosahatchee River sharks. Comparatively, only
venlafaxine was detected in the plasma of a single Myakka River shark at a
level below the limit of quantitation. These results suggest that sharks
residing in wastewater-impacted habitats accumulate APIs, a factor that may
pose special risks to C. leucas since it is one of few shark species to
regularly occupy freshwater systems. Further research is needed to determine
if the low levels of API uptake observed in Caloosahatchee River bull sharks
pose health risks to these animals.

 

 

Very truly yours,

 

Catherine Zimmer, MS, BSMT

Executive director, HEARRT Midwest

Principal, Zimmer Environmental Improvement

Improving processes, minimizing and managaing waste and, reducing costs.  

T:  651.645.7509

zenllc at usfamily.net

 

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